6t8v: Difference between revisions

<table><tr><td colspan='2'>[[6t8v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6T8V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6T8V FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.29&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MVK:4-[(2~{S})-1-[(5,7-dimethyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic+acid'>MVK</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6t8v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6t8v OCA], [https://pdbe.org/6t8v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6t8v RCSB], [https://www.ebi.ac.uk/pdbsum/6t8v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6t8v ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN] Defects in CFB are a cause of susceptibility to hemolytic uremic syndrome atypical type 4 (AHUS4) [MIM:[https://omim.org/entry/612924 612924]. An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Note=Susceptibility to the development of atypical hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the complement cascade system. Other genes may play a role in modifying the phenotype.<ref>PMID:17182750</ref> <ref>PMID:20513133</ref>  

[https://www.uniprot.org/uniprot/CFAB_HUMAN CFAB_HUMAN] Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

[[Category: Homo sapiens]]

[[Category: Adams C]]

[[Category: Adams CM]]

[[Category: Anderson K]]

[[Category: April M]]

[[Category: Argikar UA]]

[[Category: Capparelli M]]

[[Category: Crowley M]]

[[Category: Cumin F]]

[[Category: De Erkenez A]]

[[Category: Ding J]]

[[Category: Eder J]]

[[Category: Ehara T]]

[[Category: Erbel P]]

[[Category: Fang L]]

[[Category: Feifel R]]

[[Category: Ferrara L]]

[[Category: Flohr S]]

[[Category: Forster C]]

[[Category: Gerhartz B]]

[[Category: Gradoux N]]

[[Category: Harrison RA]]

[[Category: Jaffee BD]]

[[Category: Jendza K]]

[[Category: Karki RG]]

[[Category: Kawanami T]]

[[Category: Klosowski DW]]

[[Category: Lee W]]

[[Category: Liao S-M]]

[[Category: Long D]]

[[Category: Mac Sweeney A]]

[[Category: Maibaum J]]

[[Category: Mainolfi N]]

[[Category: Mogi M]]

[[Category: Powers J]]

[[Category: Prentiss M]]

[[Category: Ramage P]]

[[Category: Ramqaj R]]

[[Category: Schubart A]]

[[Category: Sedrani R]]

[[Category: Sellner H]]

[[Category: Serrano-Wu M]]

[[Category: Sirockin F]]

[[Category: Smith TM]]

[[Category: Solovay C]]

[[Category: Valeur E]]

[[Category: Vogg B]]

[[Category: Wiesmann C]]

[[Category: Yang L]]

[[Category: Zhang C]]