6rk2: Difference between revisions
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<StructureSection load='6rk2' size='340' side='right'caption='[[6rk2]], [[Resolution|resolution]] 2.09Å' scene=''> | <StructureSection load='6rk2' size='340' side='right'caption='[[6rk2]], [[Resolution|resolution]] 2.09Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6rk2]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[6rk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Agrobacterium_tumefaciens_A6 Agrobacterium tumefaciens A6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RK2 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=6GR:2-(alpha-L-altropyranosyloxy)benzoic+acid'>6GR</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rk2 OCA], [https://pdbe.org/6rk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rk2 RCSB], [https://www.ebi.ac.uk/pdbsum/6rk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rk2 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A2I4PGZ0_RHIRD A0A2I4PGZ0_RHIRD] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 6rk2" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6rk2" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Beta-glucosidase 3D structures|Beta-glucosidase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Agrobacterium tumefaciens | [[Category: Agrobacterium tumefaciens A6]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chang | [[Category: Chang CQ]] | ||
[[Category: Gao | [[Category: Gao YG]] | ||
[[Category: Wang | [[Category: Wang C]] | ||
[[Category: Ye | [[Category: Ye FZ]] | ||
[[Category: Zhang | [[Category: Zhang LH]] | ||
Latest revision as of 15:22, 24 January 2024
Complex structure of virulence factor SghA mutant with its substrate SAGComplex structure of virulence factor SghA mutant with its substrate SAG
Structural highlights
FunctionPublication Abstract from PubMedIt is highly intriguing how bacterial pathogens can quickly shut down energy-costly infection machinery once successful infection is established. This study depicts that mutation of repressor SghR increases the expression of hydrolase SghA in Agrobacterium tumefaciens, which releases plant defense signal salicylic acid (SA) from its storage form SA beta-glucoside (SAG). Addition of SA substantially reduces gene expression of bacterial virulence. Bacterial vir genes and sghA are differentially transcribed at early and later infection stages, respectively. Plant metabolite sucrose is a signal ligand that inactivates SghR and consequently induces sghA expression. Disruption of sghA leads to increased vir expression in planta and enhances tumor formation whereas mutation of sghR decreases vir expression and tumor formation. These results depict a remarkable mechanism by which A. tumefaciens taps on the reserved pool of plant signal SA to reprogram its virulence upon establishment of infection. Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals.,Wang C, Ye F, Chang C, Liu X, Wang J, Wang J, Yan XF, Fu Q, Zhou J, Chen S, Gao YG, Zhang LH Proc Natl Acad Sci U S A. 2019 Oct 11. pii: 1903695116. doi:, 10.1073/pnas.1903695116. PMID:31604827[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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