6hl0: Difference between revisions

<table><tr><td colspan='2'>[[6hl0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HL0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HL0 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.66&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hl0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hl0 OCA], [https://pdbe.org/6hl0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hl0 RCSB], [https://www.ebi.ac.uk/pdbsum/6hl0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hl0 ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/NR1H4_HUMAN NR1H4_HUMAN] Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.<ref>PMID:10334992</ref> <ref>PMID:10334993</ref> <ref>PMID:12815072</ref> <ref>PMID:15471871</ref> <ref>PMID:12718892</ref> <ref>PMID:18621523</ref> <ref>PMID:19410460</ref> <ref>PMID:19586769</ref>  

[[Category: Homo sapiens]]

[[Category: Kudlinzki D]]

[[Category: Linhard VL]]

[[Category: Merk D]]

[[Category: Saxena K]]

[[Category: Schubert-Zsilavecz M]]

[[Category: Schwalbe H]]