8ivq: Difference between revisions

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-'''Unreleased structure'''
-The entry 8ivq is ON HOLD  until Paper Publication
+==Cryo-EM structure of mouse BIRC6, Global map==
+<StructureSection load='8ivq' size='340' side='right'caption='[[8ivq]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ivq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8IVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8IVQ FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ivq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ivq OCA], [https://pdbe.org/8ivq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ivq RCSB], [https://www.ebi.ac.uk/pdbsum/8ivq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ivq ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/BIRC6_MOUSE BIRC6_MOUSE] Anti-apoptotic protein which can regulate cell death by controlling caspases and by acting as an E3 ubiquitin-protein ligase. Has an unusual ubiquitin conjugation system in that it could combine in a single polypeptide, ubiquitin conjugating (E2) with ubiquitin ligase (E3) activity, forming a chimeric E2/E3 ubiquitin ligase. Its targets include CASP9 and DIABLO/SMAC. Acts as an inhibitor of CASP3, CASP7 and CASP9. Important regulator for the final stages of cytokinesis. Crucial for normal vesicle targeting to the site of abscission, but also for the integrity of the midbody and the midbody ring, and its striking ubiquitin modification. Required for normal placenta development.<ref>PMID:15300255</ref> <ref>PMID:15485903</ref> <ref>PMID:9628897</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Mus musculus]]
+[[Category: Bu F]]
+[[Category: Gao N]]
+[[Category: Jiang T]]
+[[Category: Li N]]
+[[Category: Liu S]]
+[[Category: Qiu X]]
+[[Category: Wang G]]
+[[Category: Zhao J]]