8c7d: Difference between revisions

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'''Unreleased structure'''


The entry 8c7d is ON HOLD  until Paper Publication
==Structure of the GEF Kalirin DH2 Domain==
 
<StructureSection load='8c7d' size='340' side='right'caption='[[8c7d]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
Authors: Callens, M.C., Thompson, A.P., Gray, J.L., Bountra, C., von Delft, F., Brennan, P.E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8c7d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C7D FirstGlance]. <br>
Description: Structure of the GEF Kalirin DH2 Domain
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c7d OCA], [https://pdbe.org/8c7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c7d RCSB], [https://www.ebi.ac.uk/pdbsum/8c7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c7d ProSAT]</span></td></tr>
[[Category: Gray, J.L]]
</table>
[[Category: Callens, M.C]]
== Disease ==
[[Category: Von Delft, F]]
[https://www.uniprot.org/uniprot/KALRN_HUMAN KALRN_HUMAN] Disease susceptibility is associated with variations affecting the gene represented in this entry.
[[Category: Brennan, P.E]]
== Function ==
[[Category: Thompson, A.P]]
[https://www.uniprot.org/uniprot/KALRN_HUMAN KALRN_HUMAN] Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.<ref>PMID:10023074</ref>
[[Category: Bountra, C]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Bountra C]]
[[Category: Brennan PE]]
[[Category: Callens MC]]
[[Category: Gray JL]]
[[Category: Thompson AP]]
[[Category: Von Delft F]]

Latest revision as of 14:24, 24 January 2024

Structure of the GEF Kalirin DH2 DomainStructure of the GEF Kalirin DH2 Domain

Structural highlights

8c7d is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.86Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

KALRN_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry.

Function

KALRN_HUMAN Promotes the exchange of GDP by GTP. Activates specific Rho GTPase family members, thereby inducing various signaling mechanisms that regulate neuronal shape, growth, and plasticity, through their effects on the actin cytoskeleton. Induces lamellipodia independent of its GEF activity.[1]

References

  1. ↑ Kawai T, Sanjo H, Akira S. Duet is a novel serine/threonine kinase with Dbl-Homology (DH) and Pleckstrin-Homology (PH) domains. Gene. 1999 Feb 18;227(2):249-55. doi: 10.1016/s0378-1119(98)00605-2. PMID:10023074 doi:http://dx.doi.org/10.1016/s0378-1119(98)00605-2

8c7d, resolution 1.86Å

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