8c5r: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 8c5r is ON HOLD
+==Omicron B.1.1.529 2 RBD up conformation==
+<StructureSection load='8c5r' size='340' side='right'caption='[[8c5r]], [[Resolution|resolution]] 3.70&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8c5r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Alphacoronavirus Alphacoronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C5R FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.7&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c5r OCA], [https://pdbe.org/8c5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c5r RCSB], [https://www.ebi.ac.uk/pdbsum/8c5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c5r ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/A0A6M4AIH4_SARS2 A0A6M4AIH4_SARS2] Spike protein S1: attaches the virion to the cell membrane by interacting with host receptor, initiating the infection.[HAMAP-Rule:MF_04099]  Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.[HAMAP-Rule:MF_04099]  Spike protein S2: mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.[HAMAP-Rule:MF_04099]
+__TOC__
+</StructureSection>
+[[Category: Alphacoronavirus]]
+[[Category: Large Structures]]
+[[Category: Barfod LK]]
+[[Category: Raghavan SSR]]
+[[Category: Salanti A]]
+[[Category: Walker MR]]
+[[Category: Wang KT]]