Poly (ADP-ribose) polymerase: Difference between revisions
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PARP1 is composed of 3 domains. Among them are the N terminal DNA-binding domain which contains <scene name='43/439963/Cv/3'>5 zinc fingers (residues 1-97, 105-206, 207-366)</scene>. The auto modification (AD) domain which contains a breast cancer 1 protein (BRCT) C-terminus domain (residues 386-485) and a WGR domain (rich in Trp, Gly and Arg) (residues 517-642). The C terminal domain which includes the catalytic domain (or PARP domain) (residues 662-1011)<ref>PMID:19372272</ref>. <scene name='43/439963/Cv/6'>A potential drug binds at the active site pocket</scene><ref>PMID:24922587</ref>. | PARP1 is composed of 3 domains. Among them are the N terminal DNA-binding domain which contains <scene name='43/439963/Cv/3'>5 zinc fingers (residues 1-97, 105-206, 207-366)</scene>. The auto modification (AD) domain which contains a breast cancer 1 protein (BRCT) C-terminus domain (residues 386-485) and a WGR domain (rich in Trp, Gly and Arg) (residues 517-642). The C terminal domain which includes the catalytic domain (or PARP domain) (residues 662-1011)<ref>PMID:19372272</ref>. <scene name='43/439963/Cv/6'>A potential drug binds at the active site pocket</scene><ref>PMID:24922587</ref>. | ||
== 3D Structures of Poly (ADP-ribose) polymerase == | == 3D Structures of Poly (ADP-ribose) polymerase == | ||
[[Poly(ADP-ribose) polymerase 3D structures]] | [[Poly(ADP-ribose) polymerase 3D structures]] | ||