Band 3: Difference between revisions
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==Band 3== | ==Band 3== | ||
<StructureSection load='7rtm' size='340' side='right' caption='Band 3 dimer' scene=''> | <StructureSection load='7rtm' size='340' side='right' caption='Band 3 dimer' scene=''> | ||
'''Anion exchanger 1''' (AE1), also known as '''band 3''' or '''SLC4A1''' or Band 3 anion transport protein", exchanges chloride and bicarbonate across the red blood cell membrane, assisting in removing carbon dioxide from tissues. It also anchors the membrane skeleton <ref>PMID:34669510</ref>. Band 3's name comes from its appearance as the third major band on SDS-PAGE of red blood cell membrane proteins <ref>PMID: 4326772</ref>. | '''Anion exchanger 1''' (AE1), also known as '''band 3''' or '''SLC4A1''' or '''Band 3 anion transport protein'", exchanges chloride and bicarbonate across the red blood cell membrane, assisting in removing carbon dioxide from tissues. It also anchors the membrane skeleton <ref>PMID:34669510</ref>. Band 3's name comes from its appearance as the third major band on SDS-PAGE of red blood cell membrane proteins <ref>PMID: 4326772</ref>. | ||
Its function has been studied for more than 150 years; even so, the first complete structure was not published until 2015 <ref>PMID: 26542571</ref>, and the first crystals grown without addition of an antibody were grown on the International Space Station <ref> PMID: 30118660</ref>. | Its function has been studied for more than 150 years; even so, the first complete structure was not published until 2015 <ref>PMID: 26542571</ref>, and the first crystals grown without addition of an antibody were grown on the International Space Station <ref> PMID: 30118660</ref>. | ||