1pet: Difference between revisions

Revision as of 05:00, 3 May 2008

NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53

OverviewOverview

We report the solution structure of the minimum transforming domain (residues 303-366) of human p53 (p53tet) determined by multidimensional NMR spectroscopy. This domain contains a number of important functions associated with p53 activity including transformation, oligomerization, nuclear localization and a phosphorylation site for p34/cdc2 kinase. p53tet forms a symmetric dimer of dimers that is significantly different from a recent structure reported for a shorter construct of this domain. Phosphorylation of Ser 315 has only minor structural consequences, as this region of the protein is unstructured. Modelling based on the p53tet structure suggests possible modes of interaction between adjacent domains in full-length p53 as well as modes of interaction with DNA.

About this StructureAbout this Structure

1PET is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

ReferenceReference

Solution structure of the tetrameric minimum transforming domain of p53., Lee W, Harvey TS, Yin Y, Yau P, Litchfield D, Arrowsmith CH, Nat Struct Biol. 1994 Dec;1(12):877-90. PMID:7773777 Page seeded by OCA on Sat May 3 05:00:24 2008

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OCA

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 '''NMR SOLUTION STRUCTURE OF THE TETRAMERIC MINIMUM TRANSFORMING DOMAIN OF P53'''
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+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 05:00:24 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:58:40 2008''