1pdp: Difference between revisions
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'''Fitting of gp9 structure into the bacteriophage T4 baseplate cryoEM reconstruction''' | '''Fitting of gp9 structure into the bacteriophage T4 baseplate cryoEM reconstruction''' | ||
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[[Category: Raaij, M J.van.]] | [[Category: Raaij, M J.van.]] | ||
[[Category: Rossmann, M G.]] | [[Category: Rossmann, M G.]] | ||
[[Category: | [[Category: Structural protein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 04:58:19 2008'' | |||
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Revision as of 04:58, 3 May 2008
Fitting of gp9 structure into the bacteriophage T4 baseplate cryoEM reconstruction
OverviewOverview
The baseplate of bacteriophage T4 is a multiprotein molecular machine that controls host cell recognition, attachment, tail sheath contraction and viral DNA ejection. We report here the three-dimensional structure of the baseplate-tail tube complex determined to a resolution of 12 A by cryoelectron microscopy. The baseplate has a six-fold symmetric, dome-like structure approximately 520 A in diameter and approximately 270 A long, assembled around a central hub. A 940 A-long and 96 A-diameter tail tube, coaxial with the hub, is connected to the top of the baseplate. At the center of the dome is a needle-like structure that was previously identified as a cell puncturing device. We have identified the locations of six proteins with known atomic structures, and established the position and shape of several other baseplate proteins. The baseplate structure suggests a mechanism of baseplate triggering and structural transition during the initial stages of T4 infection.
About this StructureAbout this Structure
1PDP is a Single protein structure of sequence from Enterobacteria phage t4. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of bacteriophage T4 baseplate., Kostyuchenko VA, Leiman PG, Chipman PR, Kanamaru S, van Raaij MJ, Arisaka F, Mesyanzhinov VV, Rossmann MG, Nat Struct Biol. 2003 Sep;10(9):688-93. Epub 2003 Aug 17. PMID:12923574 Page seeded by OCA on Sat May 3 04:58:19 2008