1udu: Difference between revisions

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<StructureSection load='1udu' size='340' side='right'caption='[[1udu]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
<StructureSection load='1udu' size='340' side='right'caption='[[1udu]], [[Resolution|resolution]] 2.83&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1udu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UDU FirstGlance]. <br>
<table><tr><td colspan='2'>[[1udu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1UDU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1UDU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIA:6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1,2 1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE'>CIA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.83&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1udt|1udt]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIA:6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1,2 1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE'>CIA</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/3',5'-cyclic-nucleotide_phosphodiesterase 3',5'-cyclic-nucleotide phosphodiesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.17 3.1.4.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1udu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udu OCA], [https://pdbe.org/1udu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1udu RCSB], [https://www.ebi.ac.uk/pdbsum/1udu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1udu ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1udu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1udu OCA], [https://pdbe.org/1udu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1udu RCSB], [https://www.ebi.ac.uk/pdbsum/1udu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1udu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN]] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.  
[https://www.uniprot.org/uniprot/PDE5A_HUMAN PDE5A_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Cho, J M]]
[[Category: Cho JM]]
[[Category: Eum, S J]]
[[Category: Eum SJ]]
[[Category: Heo, Y S]]
[[Category: Heo Y-S]]
[[Category: Hwang, K Y]]
[[Category: Hwang KY]]
[[Category: Hyun, Y L]]
[[Category: Hyun Y-L]]
[[Category: Jeon, Y H]]
[[Category: Jeon YH]]
[[Category: Kim, E]]
[[Category: Kim E]]
[[Category: Kim, J H]]
[[Category: Kim JH]]
[[Category: Lee, J I]]
[[Category: Lee J-O]]
[[Category: Lee, J O]]
[[Category: Lee JI]]
[[Category: Lee, T G]]
[[Category: Lee TG]]
[[Category: Moon, J]]
[[Category: Moon J]]
[[Category: Park, S Y]]
[[Category: Park S-Y]]
[[Category: Ro, S]]
[[Category: Ro S]]
[[Category: Sung, B J]]
[[Category: Sung B-J]]
[[Category: Yoon, J M]]
[[Category: Yoon JM]]
[[Category: Cgmp-specific phosphodiesterase 5]]
[[Category: Hydrolase]]
[[Category: Selective inhibitor]]
[[Category: Tadalafil]]

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