1ize: Difference between revisions
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<StructureSection load='1ize' size='340' side='right'caption='[[1ize]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='1ize' size='340' side='right'caption='[[1ize]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1ize]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_oryzae Aspergillus oryzae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZE FirstGlance]. <br> | <table><tr><td colspan='2'>[[1ize]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Aspergillus_oryzae Aspergillus oryzae] and [https://en.wikipedia.org/wiki/Streptomyces_argenteolus_subsp._toyonakensis Streptomyces argenteolus subsp. toyonakensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IZE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IZE FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IVA:ISOVALERIC+ACID'>IVA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ize OCA], [https://pdbe.org/1ize PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ize RCSB], [https://www.ebi.ac.uk/pdbsum/1ize PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ize ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ize FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ize OCA], [https://pdbe.org/1ize PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ize RCSB], [https://www.ebi.ac.uk/pdbsum/1ize PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ize ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PEPA_ASPOZ PEPA_ASPOZ] Secreted aspartic endopeptidase that allows assimilation of proteinaceous substrates. The scissile peptide bond is attacked by a nucleophilic water molecule activated by two aspartic residues in the active site. Shows a broad primary substrate specificity. Favors hydrophobic residues at the P1 and P1' positions, but also accepts a lysine residue in the P1 position, leading to the activation of trypsinogen and chymotrypsinogen A.[UniProtKB:Q12567] | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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==See Also== | ==See Also== | ||
*[[Proteinase 3D structures|Proteinase 3D structures]] | *[[Proteinase 3D structures|Proteinase 3D structures]] | ||
== References == | == References == | ||
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[[Category: Aspergillus oryzae]] | [[Category: Aspergillus oryzae]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ino | [[Category: Streptomyces argenteolus subsp. toyonakensis]] | ||
[[Category: Kamitori | [[Category: Ino H]] | ||
[[Category: Ohtaki | [[Category: Kamitori S]] | ||
[[Category: Takeuchi | [[Category: Ohtaki A]] | ||
[[Category: Takeuchi M]] | |||