1ci5: Difference between revisions

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==GLYCAN-FREE MUTANT ADHESION DOMAIN OF HUMAN CD58 (LFA-3)==
==GLYCAN-FREE MUTANT ADHESION DOMAIN OF HUMAN CD58 (LFA-3)==
<StructureSection load='1ci5' size='340' side='right'caption='[[1ci5]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1ci5' size='340' side='right'caption='[[1ci5]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1ci5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CI5 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1ci5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CI5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CI5 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ci5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci5 OCA], [https://pdbe.org/1ci5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ci5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ci5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci5 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ci5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ci5 OCA], [https://pdbe.org/1ci5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ci5 RCSB], [https://www.ebi.ac.uk/pdbsum/1ci5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ci5 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LFA3_HUMAN LFA3_HUMAN]] Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.  
[https://www.uniprot.org/uniprot/LFA3_HUMAN LFA3_HUMAN] Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and -dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Dotsch, V]]
[[Category: Dotsch V]]
[[Category: Kim, M]]
[[Category: Kim M]]
[[Category: Li, J]]
[[Category: Li J]]
[[Category: Reinherz, E L]]
[[Category: Reinherz EL]]
[[Category: Sun, Z Y.J]]
[[Category: Sun ZYJ]]
[[Category: Wagner, G]]
[[Category: Wagner G]]
[[Category: Adhesion glycoprotein]]
[[Category: Cell surface receptor]]
[[Category: Immune system]]
[[Category: Immunoglobulin superfamily v-set domain]]

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