4tvm: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4tvm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TVM FirstGlance]. <br> | <table><tr><td colspan='2'>[[4tvm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TVM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvm OCA], [https://pdbe.org/4tvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tvm RCSB], [https://www.ebi.ac.uk/pdbsum/4tvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tvm ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tvm OCA], [https://pdbe.org/4tvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tvm RCSB], [https://www.ebi.ac.uk/pdbsum/4tvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tvm ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 15:25, 20 December 2023
Structure of Citrate Synthase from Mycobacterium tuberculosisStructure of Citrate Synthase from Mycobacterium tuberculosis
Structural highlights
FunctionPublication Abstract from PubMedThe tricarboxylic acid (TCA) cycle is a central metabolic pathway of all aerobic organisms and is responsible for the synthesis of many important precursors and molecules. TCA cycle plays a key role in the metabolism of M. tuberculosis and is involved in the adaptation process of the bacteria to the host immune response. We present here the first crystal structures of M. tuberculosis malate dehydrogenase and citrate synthase, two consecutive enzymes of the tricarboxylic acid cycle, at 2.6 A and 1.5 A resolution, respectively. General analogies and local differences with the previously reported homologous protein structures are described. This article is protected by copyright. All rights reserved. Structures of citrate synthase and malate dehydrogenase of mycobacterium tuberculosis.,Ferraris DM, Spallek R, Oehlmann W, Singh M, Rizzi M Proteins. 2014 Dec 18. doi: 10.1002/prot.24743. PMID:25524525[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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