4axf: Difference between revisions

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<StructureSection load='4axf' size='340' side='right'caption='[[4axf]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
<StructureSection load='4axf' size='340' side='right'caption='[[4axf]], [[Resolution|resolution]] 2.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4axf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AXF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4axf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AXF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AXF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4MY:MYO+INOSITOL+3,4,5,6+TETRAKISPHOSPHATE'>4MY</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.93&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2xal|2xal]], [[2xam|2xam]], [[2xan|2xan]], [[2xao|2xao]], [[2xar|2xar]], [[4aqk|4aqk]], [[4axc|4axc]], [[4axd|4axd]], [[4axe|4axe]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4MY:MYO+INOSITOL+3,4,5,6+TETRAKISPHOSPHATE'>4MY</scene>, <scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Inositol-pentakisphosphate_2-kinase Inositol-pentakisphosphate 2-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.158 2.7.1.158] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4axf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axf OCA], [https://pdbe.org/4axf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4axf RCSB], [https://www.ebi.ac.uk/pdbsum/4axf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4axf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4axf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4axf OCA], [https://pdbe.org/4axf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4axf RCSB], [https://www.ebi.ac.uk/pdbsum/4axf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4axf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH]] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>
[https://www.uniprot.org/uniprot/IPPK_ARATH IPPK_ARATH] Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). Phytate is a regulator of intracellular signaling, a highly abundant animal antinutrient, and a phosphate store in plant seeds. Also phosphorylates Ins(1,3,4,6)P4 and Ins(1,4,5,6)P4 to produce Ins(1,2,3,4,6)P5 and Ins(1,2,4,5,6)P5.<ref>PMID:16107538</ref> <ref>PMID:16223361</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Arath]]
[[Category: Arabidopsis thaliana]]
[[Category: Inositol-pentakisphosphate 2-kinase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Banos-Sanz, J I]]
[[Category: Gonzalez B]]
[[Category: Gonzalez, B]]
[[Category: I Banos-Sanz J]]
[[Category: Sanz-Aparicio, J]]
[[Category: Sanz-Aparicio J]]
[[Category: Inositide signalling]]
[[Category: Inositol kinase]]
[[Category: Phytic acid]]
[[Category: Protein kinase]]
[[Category: Transferase]]

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