4ahy: Difference between revisions
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<StructureSection load='4ahy' size='340' side='right'caption='[[4ahy]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='4ahy' size='340' side='right'caption='[[4ahy]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4ahy]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AHY FirstGlance]. <br> | <table><tr><td colspan='2'>[[4ahy]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AHY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4AHY FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GD:GADOLINIUM+ATOM'>GD</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ahy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahy OCA], [https://pdbe.org/4ahy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ahy RCSB], [https://www.ebi.ac.uk/pdbsum/4ahy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahy ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ahy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ahy OCA], [https://pdbe.org/4ahy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ahy RCSB], [https://www.ebi.ac.uk/pdbsum/4ahy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ahy ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/FLO5_YEAST FLO5_YEAST] Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Saccharomyces cerevisiae S288C]] | ||
[[Category: | [[Category: Essen L-O]] | ||
[[Category: | [[Category: Veelders M]] | ||
Latest revision as of 14:27, 20 December 2023
Flo5A cocrystallized with 3 mM GdAc3Flo5A cocrystallized with 3 mM GdAc3
Structural highlights
FunctionFLO5_YEAST Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2+)-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin-like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells. Activity is inhibited by mannose, but not by glucose, maltose, sucrose or galactose. Publication Abstract from PubMedProtein-bound contrast: The unusual observation of a heptanuclear gadolinium-oxo cluster on the surface of the cell-adhesion protein Flo5A establishes the basis for directed incorporation of poly-lanthanide clusters into biomolecules. The observed gadolinium cluster might serve as a paradigm for the design of protein-based MRI contrast agents. Complex Gadolinium-Oxo Clusters Formed along Concave Protein Surfaces.,Veelders M, Essen LO Chembiochem. 2012 Aug 31. doi: 10.1002/cbic.201200441. PMID:22936626[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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