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<StructureSection load='4a23' size='340' side='right'caption='[[4a23]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='4a23' size='340' side='right'caption='[[4a23]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4a23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A23 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4a23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4A23 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C56:4-(DIMETHYLAMINO)-N-{[(2R)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2-METHOXY-5-NITROBENZAMIDE'>C56</scene>, <scene name='pdbligand=C57:4-(DIMETHYLAMINO)-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2-METHOXY-5-NITROBENZAMIDE'>C57</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jgh|2jgh]], [[2whq|2whq]], [[1mah|1mah]], [[1maa|1maa]], [[2ha6|2ha6]], [[2c0q|2c0q]], [[2jgg|2jgg]], [[2jgl|2jgl]], [[2xug|2xug]], [[1q84|1q84]], [[2xud|2xud]], [[2jgm|2jgm]], [[2xuj|2xuj]], [[2jge|2jge]], [[1q83|1q83]], [[2wls|2wls]], [[2xup|2xup]], [[2xuk|2xuk]], [[1c2b|1c2b]], [[2y2u|2y2u]], [[2ha3|2ha3]], [[2ha0|2ha0]], [[2wu3|2wu3]], [[2xuf|2xuf]], [[2jey|2jey]], [[2jgi|2jgi]], [[1n5r|1n5r]], [[2xuh|2xuh]], [[2jgj|2jgj]], [[1j06|1j06]], [[2c0p|2c0p]], [[2jf0|2jf0]], [[2xuo|2xuo]], [[2h9y|2h9y]], [[2whr|2whr]], [[2xui|2xui]], [[1n5m|1n5m]], [[2ha5|2ha5]], [[2ha2|2ha2]], [[2xuq|2xuq]], [[2whp|2whp]], [[2jez|2jez]], [[2jgk|2jgk]], [[1ku6|1ku6]], [[2ha4|2ha4]], [[1j07|1j07]], [[2ha7|2ha7]], [[2jgf|2jgf]], [[2y2v|2y2v]], [[2wu4|2wu4]], [[1c2o|1c2o]], [[4a16|4a16]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=C56:4-(DIMETHYLAMINO)-N-{[(2R)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2-METHOXY-5-NITROBENZAMIDE'>C56</scene>, <scene name='pdbligand=C57:4-(DIMETHYLAMINO)-N-{[(2S)-1-ETHYLPYRROLIDIN-2-YL]METHYL}-2-METHOXY-5-NITROBENZAMIDE'>C57</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a23 OCA], [https://pdbe.org/4a23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a23 RCSB], [https://www.ebi.ac.uk/pdbsum/4a23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a23 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4a23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a23 OCA], [https://pdbe.org/4a23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4a23 RCSB], [https://www.ebi.ac.uk/pdbsum/4a23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4a23 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.  
[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acetylcholinesterase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Andersson, C D]]
[[Category: Andersson CD]]
[[Category: Artrursson, E]]
[[Category: Artrursson E]]
[[Category: Berg, L]]
[[Category: Berg L]]
[[Category: Ekstrom, F]]
[[Category: Ekstrom F]]
[[Category: Hornberg, A]]
[[Category: Hornberg A]]
[[Category: Linusson, A]]
[[Category: Linusson A]]
[[Category: Tunemalm, A K]]
[[Category: Tunemalm AK]]
[[Category: Cholinesterase]]
[[Category: Hydrolase]]

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