2xjw: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2xjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XJW FirstGlance]. <br>
<table><tr><td colspan='2'>[[2xjw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XJW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XJW FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.67&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w6z|1w6z]], [[1kxx|1kxx]], [[4lyo|4lyo]], [[3lyo|3lyo]], [[1kip|1kip]], [[1t6v|1t6v]], [[1vds|1vds]], [[1ic7|1ic7]], [[1lzt|1lzt]], [[1kir|1kir]], [[2xbr|2xbr]], [[1lys|1lys]], [[132l|132l]], [[1e8l|1e8l]], [[1bwj|1bwj]], [[1yil|1yil]], [[1heo|1heo]], [[1sfg|1sfg]], [[1kxw|1kxw]], [[2x0a|2x0a]], [[2c8o|2c8o]], [[1g7l|1g7l]], [[1yl1|1yl1]], [[1sf4|1sf4]], [[1ior|1ior]], [[1h87|1h87]], [[1ljg|1ljg]], [[3lyt|3lyt]], [[1iot|1iot]], [[1dpx|1dpx]], [[1v7s|1v7s]], [[1ja6|1ja6]], [[1jis|1jis]], [[1ir8|1ir8]], [[2w1m|2w1m]], [[1uic|1uic]], [[1ykz|1ykz]], [[1xgq|1xgq]], [[1uie|1uie]], [[2war|2war]], [[1lji|1lji]], [[1lj3|1lj3]], [[1dpw|1dpw]], [[8lyz|8lyz]], [[1bwi|1bwi]], [[2iff|2iff]], [[2lyo|2lyo]], [[1g7h|1g7h]], [[1lks|1lks]], [[1jj0|1jj0]], [[1rfp|1rfp]], [[5lyt|5lyt]], [[1sfb|1sfb]], [[1jiy|1jiy]], [[1ir7|1ir7]], [[1iee|1iee]], [[1xei|1xei]], [[1hel|1hel]], [[1xek|1xek]], [[1at6|1at6]], [[1ljf|1ljf]], [[1mlc|1mlc]], [[2b5z|2b5z]], [[1f10|1f10]], [[1lsz|1lsz]], [[193l|193l]], [[1ljk|1ljk]], [[6lyt|6lyt]], [[1sq2|1sq2]], [[1vdq|1vdq]], [[1zmy|1zmy]], [[1lje|1lje]], [[2xth|2xth]], [[2d91|2d91]], [[1lze|1lze]], [[1b2k|1b2k]], [[1aki|1aki]], [[1uia|1uia]], [[1hen|1hen]], [[1yik|1yik]], [[1xfp|1xfp]], [[2d6b|2d6b]], [[1ndg|1ndg]], [[1lpi|1lpi]], [[1lsd|1lsd]], [[1flw|1flw]], [[2blx|2blx]], [[6lyz|6lyz]], [[1nbz|1nbz]], [[1lsg|1lsg]], [[4lyt|4lyt]], [[3hfm|3hfm]], [[1ved|1ved]], [[1jit|1jit]], [[1lzn|1lzn]], [[1wtn|1wtn]], [[1ja2|1ja2]], [[1uuz|1uuz]], [[1lyz|1lyz]], [[2d4i|2d4i]], [[2xbs|2xbs]], [[2fbb|2fbb]], [[1fdl|1fdl]], [[2lym|2lym]], [[1gxx|1gxx]], [[1lz9|1lz9]], [[1lse|1lse]], [[1lzh|1lzh]], [[1lsm|1lsm]], [[1jj3|1jj3]], [[7lyz|7lyz]], [[3lym|3lym]], [[1yky|1yky]], [[1kiq|1kiq]], [[1t3p|1t3p]], [[1heq|1heq]], [[2lzh|2lzh]], [[1uih|1uih]], [[1kxy|1kxy]], [[2w1l|2w1l]], [[1g7j|1g7j]], [[1b0d|1b0d]], [[2bly|2bly]], [[1her|1her]], [[1bhz|1bhz]], [[1wtm|1wtm]], [[1nby|1nby]], [[1ioq|1ioq]], [[1hep|1hep]], [[1jtt|1jtt]], [[1qio|1qio]], [[1lza|1lza]], [[1xgp|1xgp]], [[1ps5|1ps5]], [[1gwd|1gwd]], [[1jpo|1jpo]], [[1v7t|1v7t]], [[1h6m|1h6m]], [[1dqj|1dqj]], [[1j1p|1j1p]], [[2a7d|2a7d]], [[1ljj|1ljj]], [[1z55|1z55]], [[2c8p|2c8p]], [[1lsb|1lsb]], [[1f0w|1f0w]], [[2w1x|2w1x]], [[1flq|1flq]], [[1lzg|1lzg]], [[1lzc|1lzc]], [[1jj1|1jj1]], [[1rcm|1rcm]], [[1uid|1uid]], [[1yqv|1yqv]], [[1bgi|1bgi]], [[1hsx|1hsx]], [[1lzd|1lzd]], [[1lcn|1lcn]], [[1hew|1hew]], [[2cds|2cds]], [[2vb1|2vb1]], [[2aub|2aub]], [[1uib|1uib]], [[1hf4|1hf4]], [[1j1x|1j1x]], [[1ios|1ios]], [[1rjc|1rjc]], [[2cgi|2cgi]], [[1ir9|1ir9]], [[1uc0|1uc0]], [[1azf|1azf]], [[1ic4|1ic4]], [[1ljh|1ljh]], [[4lyz|4lyz]], [[1gpq|1gpq]], [[2a6u|2a6u]], [[2d4k|2d4k]], [[1xej|1xej]], [[1ja7|1ja7]], [[1mel|1mel]], [[1ri8|1ri8]], [[1uig|1uig]], [[1bvx|1bvx]], [[1qtk|1qtk]], [[1c10|1c10]], [[1lkr|1lkr]], [[1lyo|1lyo]], [[1n4f|1n4f]], [[1hsw|1hsw]], [[1g7m|1g7m]], [[2w1y|2w1y]], [[1jto|1jto]], [[1sf7|1sf7]], [[1lsf|1lsf]], [[1fn5|1fn5]], [[2d4j|2d4j]], [[5lyz|5lyz]], [[3lzt|3lzt]], [[1c08|1c08]], [[1ndm|1ndm]], [[1sf6|1sf6]], [[3lyz|3lyz]], [[1bvk|1bvk]], [[1uif|1uif]], [[1vau|1vau]], [[2lyz|2lyz]], [[1lma|1lma]], [[1fly|1fly]], [[1hc0|1hc0]], [[1j1o|1j1o]], [[1yl0|1yl0]], [[2lzt|2lzt]], [[1a2y|1a2y]], [[4lzt|4lzt]], [[1lsy|1lsy]], [[1uco|1uco]], [[1gxv|1gxv]], [[1ic5|1ic5]], [[1lsa|1lsa]], [[1p2c|1p2c]], [[5lym|5lym]], [[1ua6|1ua6]], [[1at5|1at5]], [[1vat|1vat]], [[1lj4|1lj4]], [[1f3j|1f3j]], [[1hem|1hem]], [[1vfb|1vfb]], [[1ja4|1ja4]], [[2a7f|2a7f]], [[4lym|4lym]], [[194l|194l]], [[1flu|1flu]], [[1lz8|1lz8]], [[1ykx|1ykx]], [[1vdt|1vdt]], [[2hfm|2hfm]], [[1bwh|1bwh]], [[1io5|1io5]], [[1lsn|1lsn]], [[1lzb|1lzb]], [[2bpu|2bpu]], [[1g7i|1g7i]], [[1lsc|1lsc]], [[1vdp|1vdp]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=RU:RUTHENIUM+ION'>RU</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjw OCA], [https://pdbe.org/2xjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xjw RCSB], [https://www.ebi.ac.uk/pdbsum/2xjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjw ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xjw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xjw OCA], [https://pdbe.org/2xjw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xjw RCSB], [https://www.ebi.ac.uk/pdbsum/2xjw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xjw ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK]] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>
[https://www.uniprot.org/uniprot/LYSC_CHICK LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.<ref>PMID:22044478</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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[[Category: Gallus gallus]]
[[Category: Gallus gallus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Lysozyme]]
[[Category: Mukhopadhyay A]]
[[Category: Mukhopadhyay, A]]
[[Category: Romao MJ]]
[[Category: Romao, M J]]
[[Category: Santos-Silva T]]
[[Category: Santos-Silva, T]]
[[Category: Hydrolase]]
[[Category: Metal-protein adduct]]

Latest revision as of 13:32, 20 December 2023

Lysozyme-CO releasing molecule adductLysozyme-CO releasing molecule adduct

Structural highlights

2xjw is a 1 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.67Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LYSC_CHICK Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.[1]

Publication Abstract from PubMed

CORM-3, [fac-Ru(CO)(3)Cl(kappa(2)-H(2)NCH(2)CO(2))], is a well-known carbon monoxide releasing molecule (CORM) capable of delivering CO in vivo. Herein we show for the first time that the interactions of CORM-3 with proteins result in the loss of a chloride ion, glycinate, and one CO ligand. The rapid formation of stable adducts between the protein and the remaining cis-Ru(II)(CO)(2) fragments was confirmed by Inductively Coupled Plasma-Atomic Emission Spectrocopy (ICP-AES), Liquid-Chromatography Mass Spectrometry (LC-MS), Infrared Spectroscopy (IR), and X-ray crystallography. Three Ru coordination sites are observed in the structure of hen egg white lysozyme crystals soaked with CORM-3. The site with highest Ru occupancy (80%) shows a fac-[(His15)Ru(CO)(2)(H(2)O)(3)] structure.

CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysozyme Complex.,Santos-Silva T, Mukhopadhyay A, Seixas JD, Bernardes GJ, Romao CC, Romao MJ J Am Chem Soc. 2011 Jan 4. PMID:21204537[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021
  2. ↑ Santos-Silva T, Mukhopadhyay A, Seixas JD, Bernardes GJ, Romao CC, Romao MJ. CORM-3 Reactivity toward Proteins: The Crystal Structure of a Ru(II) Dicarbonyl-Lysozyme Complex. J Am Chem Soc. 2011 Jan 4. PMID:21204537 doi:10.1021/ja108820s

2xjw, resolution 1.67Å

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