8hoc: Difference between revisions

Revision as of 13:01, 20 December 2023

Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complexCryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex

Structural highlights

8hoc is a 5 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GNAI1_HUMAN Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.^[1] ^[2]

References

↑ Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114
↑ Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

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OCA

[1] Cho H, Kehrl JH. Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. J Cell Biol. 2007 Jul 16;178(2):245-55. PMID:17635935 doi:10.1083/jcb.200604114

[2] Johnston CA, Siderovski DP. Structural basis for nucleotide exchange on G alpha i subunits and receptor coupling specificity. Proc Natl Acad Sci U S A. 2007 Feb 6;104(6):2001-6. Epub 2007 Jan 30. PMID:17264214

[1]

[2]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8hoc is ON HOLD  until Paper Publication
+==Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex==
+<StructureSection load='8hoc' size='340' side='right'caption='[[8hoc]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8hoc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8HOC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8HOC FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ITF:2-(1~{H}-imidazol-5-yl)ethyl+carbamimidothioate'>ITF</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8hoc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8hoc OCA], [https://pdbe.org/8hoc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8hoc RCSB], [https://www.ebi.ac.uk/pdbsum/8hoc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8hoc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/GNAI1_HUMAN GNAI1_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. May play a role in cell division.<ref>PMID:17635935</ref> <ref>PMID:17264214</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Li FH]]
+[[Category: Sun XY]]
+[[Category: Tang WQ]]
+[[Category: Wang JY]]

8hoc: Difference between revisions

Revision as of 13:01, 20 December 2023

Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complexCryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex

Structural highlights

Function

References

Contents

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8hoc: Difference between revisions

Revision as of 13:01, 20 December 2023

Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complexCryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex

Structural highlights

Function

References

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