7q5r: Difference between revisions
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<StructureSection load='7q5r' size='340' side='right'caption='[[7q5r]], [[Resolution|resolution]] 3.84Å' scene=''> | <StructureSection load='7q5r' size='340' side='right'caption='[[7q5r]], [[Resolution|resolution]] 3.84Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7q5r]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[7q5r]] is a 60 chain structure with sequence from [https://en.wikipedia.org/wiki/Chaetomium_thermophilum_var._thermophilum_DSM_1495 Chaetomium thermophilum var. thermophilum DSM 1495]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q5R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q5R FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.84Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q5r OCA], [https://pdbe.org/7q5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q5r RCSB], [https://www.ebi.ac.uk/pdbsum/7q5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q5r ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q5r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q5r OCA], [https://pdbe.org/7q5r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q5r RCSB], [https://www.ebi.ac.uk/pdbsum/7q5r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q5r ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ODP2_CHATD ODP2_CHATD] The 10-megadalton pyruvate dehydrogenase complex contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3) and catalyzes the overall oxidative decarboxylation of pyruvate to form acetyl-CoA and CO(2) (PubMed:33567276, PubMed:34836937, PubMed:35093201). Within the complex, pyruvate and thiamine pyrophosphate (TPP or vitamin B1) are bound by pyruvate dehydrogenase E1 subunits alpha and beta and pyruvate is decarboxylated leading to the 2-carbon hydrohyethyl bound to TPP. The E2 component contains covalently-bound lipoyl cofactors and transfers the hydroxyethyl group from TPP to an oxidized form of covalently bound lipoamide, and the resulting acetyl group is then transferred to free coenzyme A to form acetyl-CoA and reduced dihydrolipoamide-E2. Finally, the flavoprotein dihydrolipoamide dehydrogenase (E3) re-oxidizes the lipoyl group of dihydrolipoamide-E2 to form lipoamide-E2 and NADH. A fourth subunit, E3BP, is responsible for tethering E3 in proximity to the core, forming the entire metabolon (Probable).<ref>PMID:33567276</ref> <ref>PMID:34836937</ref> <ref>PMID:35093201</ref> <ref>PMID:33567276</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 7q5r" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7q5r" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Pyruvate dehydrogenase 3D structures|Pyruvate dehydrogenase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Chaetomium thermophilum var. thermophilum DSM 1495]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Chojnowski | [[Category: Chojnowski G]] | ||
[[Category: Hamdi | [[Category: Hamdi F]] | ||
[[Category: Kastritis | [[Category: Kastritis PL]] | ||
[[Category: Kyrilis | [[Category: Kyrilis FL]] | ||
[[Category: Skalidis | [[Category: Skalidis I]] | ||
[[Category: Tueting | [[Category: Tueting C]] | ||