7ber: Difference between revisions

<table><tr><td colspan='2'>[[7ber]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BER OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BER FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Defects in MYD88 are the cause of MYD88 deficiency (MYD88D) [MIM:[https://omim.org/entry/612260 612260]; also known as recurrent pyogenic bacterial infections due to MYD88 deficiency. Patients suffer from autosomal recessive, life-threatening, often recurrent pyogenic bacterial infections, including invasive pneumococcal disease, and die between 1 and 11 months of age. Surviving patients are otherwise healthy, with normal resistance to other microbes, and their clinical status improved with age.<ref>PMID:19506249</ref> <ref>PMID:18669862</ref>  

[https://www.uniprot.org/uniprot/MYD88_HUMAN MYD88_HUMAN] Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity).<ref>PMID:9013863</ref> <ref>PMID:15361868</ref> <ref>PMID:18292575</ref> <ref>PMID:19506249</ref>  

[[Category: Homo sapiens]]

[[Category: Abbey B]]

[[Category: Aquila A]]

[[Category: Clabbers MTB]]

[[Category: Croll TI]]

[[Category: Darmanin C]]

[[Category: Gambin Y]]

[[Category: Holmes S]]

[[Category: Hunter DJB]]

[[Category: Hunter MS]]

[[Category: Kobe B]]

[[Category: Liang M]]

[[Category: Malde AK]]

[[Category: Muusse TW]]

[[Category: Nanson JD]]

[[Category: Rahaman MH]]

[[Category: Sierecki E]]

[[Category: Thygesen SJ]]

[[Category: Vajjhala P]]

[[Category: Ve T]]

[[Category: Xu H]]

[[Category: Yoon CH]]

[[Category: Zatsepin NA]]

[[Category: Zhao J]]