2wgp: Difference between revisions
No edit summary |
No edit summary |
||
| Line 3: | Line 3: | ||
<StructureSection load='2wgp' size='340' side='right'caption='[[2wgp]], [[Resolution|resolution]] 1.88Å' scene=''> | <StructureSection load='2wgp' size='340' side='right'caption='[[2wgp]], [[Resolution|resolution]] 1.88Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wgp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2wgp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WGP FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.88Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgp OCA], [https://pdbe.org/2wgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgp RCSB], [https://www.ebi.ac.uk/pdbsum/2wgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wgp OCA], [https://pdbe.org/2wgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wgp RCSB], [https://www.ebi.ac.uk/pdbsum/2wgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wgp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/DUS14_HUMAN DUS14_HUMAN] Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 30: | Line 31: | ||
==See Also== | ==See Also== | ||
*[[Dual specificity phosphatase 3D structures|Dual specificity phosphatase 3D structures]] | |||
*[[MAP kinase phosphatase|MAP kinase phosphatase]] | *[[MAP kinase phosphatase|MAP kinase phosphatase]] | ||
== References == | == References == | ||
| Line 35: | Line 37: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cherry | [[Category: Cherry S]] | ||
[[Category: Lountos | [[Category: Lountos GT]] | ||
[[Category: Tropea | [[Category: Tropea JE]] | ||
[[Category: Waugh | [[Category: Waugh DS]] | ||
Latest revision as of 18:55, 13 December 2023
Crystal structure of human dual specificity phosphatase 14Crystal structure of human dual specificity phosphatase 14
Structural highlights
FunctionDUS14_HUMAN Involved in the inactivation of MAP kinases. Dephosphorylates ERK, JNK and p38 MAP-kinases. Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedDual-specificity phosphatases (DUSPs) are enzymes that participate in the regulation of biological processes such as cell growth, differentiation, transcription and metabolism. A number of DUSPs are able to dephosphorylate phosphorylated serine, threonine and tyrosine residues on mitogen-activated protein kinases (MAPKs) and thus are also classified as MAPK phosphatases (MKPs). As an increasing number of DUSPs are being identified and characterized, there is a growing need to understand their biological activities at the molecular level. There is also significant interest in identifying DUSPs that could be potential targets for drugs that modulate MAPK-dependent signaling and immune responses, which have been implicated in a variety of maladies including cancer, infectious diseases and inflammatory disorders. Here, the overproduction, purification and crystal structure at 1.88 A resolution of human dual-specificity phosphatase 14, DUSP14 (MKP6), are reported. This structural information should accelerate the study of DUSP14 at the molecular level and may also accelerate the discovery and development of novel therapeutic agents. Overproduction, purification and structure determination of human dual-specificity phosphatase 14.,Lountos GT, Tropea JE, Cherry S, Waugh DS Acta Crystallogr D Biol Crystallogr. 2009 Oct;65(Pt 10):1013-20. Epub 2009, Sep 16. PMID:19770498[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
|
| ||||||||||||||||||