2wd7: Difference between revisions

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<StructureSection load='2wd7' size='340' side='right'caption='[[2wd7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='2wd7' size='340' side='right'caption='[[2wd7]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2wd7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trybb Trybb]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WD7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2wd7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WD7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=VGD:6-CHLORO-1H-BENZIMIDAZOL-2-AMINE'>VGD</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=VGD:6-CHLORO-1H-BENZIMIDAZOL-2-AMINE'>VGD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2vz0|2vz0]], [[2c7v|2c7v]], [[2wd8|2wd8]]</div></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Pteridine_reductase Pteridine reductase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.33 1.5.1.33] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd7 OCA], [https://pdbe.org/2wd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd7 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wd7 OCA], [https://pdbe.org/2wd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2wd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wd7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O76290_TRYBB O76290_TRYBB]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pteridine reductase]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Trybb]]
[[Category: Brenk R]]
[[Category: Brenk, R]]
[[Category: Robinson DA]]
[[Category: Robinson, D A]]
[[Category: Spinks D]]
[[Category: Spinks, D]]
[[Category: Wyatt PG]]
[[Category: Wyatt, P G]]
[[Category: Drug discovery]]
[[Category: Methotrexate resistance]]
[[Category: Oxidoreductase]]
[[Category: Short-chain dehydrogenase/reductase]]
[[Category: Trypanosomatid]]

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