2w4f: Difference between revisions
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<StructureSection load='2w4f' size='340' side='right'caption='[[2w4f]], [[Resolution|resolution]] 1.30Å' scene=''> | <StructureSection load='2w4f' size='340' side='right'caption='[[2w4f]], [[Resolution|resolution]] 1.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2w4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2w4f]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4F FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4f OCA], [https://pdbe.org/2w4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4f RCSB], [https://www.ebi.ac.uk/pdbsum/2w4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4f ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4f OCA], [https://pdbe.org/2w4f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4f RCSB], [https://www.ebi.ac.uk/pdbsum/2w4f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4f ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/SCRIB_HUMAN SCRIB_HUMAN] Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. Most probably functions in the establishment of apico-basal cell polarity. May function in cell proliferation regulating progression from G1 to S phase and as a positive regulator of apoptosis for instance during acinar morphogenesis of the mammary epithelium. May also function in cell migration and adhesion and hence regulate cell invasion through MAPK signaling. May play a role in exocytosis and in the targeting synaptic vesicles to synapses. Functions as an activator of Rac GTPase activity.<ref>PMID:15182672</ref> <ref>PMID:15775968</ref> <ref>PMID:16344308</ref> <ref>PMID:16965391</ref> <ref>PMID:18641685</ref> <ref>PMID:18716323</ref> <ref>PMID:19041750</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w4f ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2w4f ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Bray | [[Category: Bray J]] | ||
[[Category: Cooper | [[Category: Cooper C]] | ||
[[Category: Doyle DA]] | |||
[[Category: Doyle | [[Category: Edwards AM]] | ||
[[Category: Edwards | [[Category: Elkins JM]] | ||
[[Category: Elkins | [[Category: Hozjan V]] | ||
[[Category: Hozjan | [[Category: Muniz JRC]] | ||
[[Category: Muniz | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Phillips C]] | ||
[[Category: Phillips | [[Category: Pilka ES]] | ||
[[Category: Pilka | [[Category: Roos AK]] | ||
[[Category: Roos | [[Category: Salah E]] | ||
[[Category: Salah | [[Category: W Yue W]] | ||
[[Category: | [[Category: Weigelt J]] | ||
[[Category: Von Delft F]] | |||
[[Category: | |||
[[Category: | |||