2w4b: Difference between revisions
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<StructureSection load='2w4b' size='340' side='right'caption='[[2w4b]], [[Resolution|resolution]] 3.50Å' scene=''> | <StructureSection load='2w4b' size='340' side='right'caption='[[2w4b]], [[Resolution|resolution]] 3.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2w4b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2w4b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_herpesvirus_4_strain_B95-8 Human herpesvirus 4 strain B95-8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2W4B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2W4B FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.5Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4b OCA], [https://pdbe.org/2w4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4b RCSB], [https://www.ebi.ac.uk/pdbsum/2w4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4b ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2w4b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2w4b OCA], [https://pdbe.org/2w4b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2w4b RCSB], [https://www.ebi.ac.uk/pdbsum/2w4b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2w4b ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/AN_EBVB9 AN_EBVB9] Displays DNase activity required for viral genome processing in the nucleus. Plays a role in processing non linear or branched viral DNA intermediates and in capsid egress from the host nucleus. Exhibits endonuclease and exonuclease activities and accepts both double-stranded and single-stranded DNA as substrate. Exonuclease digestion of DNA is in the 5'-> 3' direction and the products are 5'-monophosphate nucleosides. Also acts as a cytoplasmic RNA endonuclease that induces degradation of the majority of the cellular messenger RNAs during lytic infection. The resulting inhibition of cellular protein synthesis serves to ensure maximal viral gene expression and evasion from host immune response.<ref>PMID:19264771</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human herpesvirus 4 strain B95-8]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Buisson | [[Category: Buisson M]] | ||
[[Category: Burmeister | [[Category: Burmeister WP]] | ||
[[Category: Flot | [[Category: Flot D]] | ||
[[Category: Geoui | [[Category: Geoui T]] | ||
[[Category: Tarbouriech | [[Category: Tarbouriech N]] | ||