2vgp: Difference between revisions
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<StructureSection load='2vgp' size='340' side='right'caption='[[2vgp]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2vgp' size='340' side='right'caption='[[2vgp]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2vgp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2vgp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VGP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VGP FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AD6:4-[(5-BROMO-1,3-THIAZOL-2-YL)AMINO]-N-METHYLBENZAMIDE'>AD6</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vgp OCA], [https://pdbe.org/2vgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vgp RCSB], [https://www.ebi.ac.uk/pdbsum/2vgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vgp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vgp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vgp OCA], [https://pdbe.org/2vgp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vgp RCSB], [https://www.ebi.ac.uk/pdbsum/2vgp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vgp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/AUKBA_XENLA AUKBA_XENLA] Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis. Required for central/midzone spindle assembly and cleavage furrow formation. Phosphorylates 'Ser-10' of histone H3 during mitosis.<ref>PMID:12221116</ref> <ref>PMID:11350965</ref> <ref>PMID:17199039</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Xenopus laevis]] | ||
[[Category: Andersen | [[Category: Andersen CB]] | ||
[[Category: Chang | [[Category: Chang JW]] | ||
[[Category: Gray | [[Category: Gray NS]] | ||
[[Category: Lee | [[Category: Lee C]] | ||
[[Category: Liu | [[Category: Liu Y]] | ||
[[Category: Musacchio | [[Category: Musacchio A]] | ||
[[Category: Nallan | [[Category: Nallan L]] | ||
[[Category: Sessa | [[Category: Sessa F]] | ||
[[Category: Villa | [[Category: Villa F]] | ||
[[Category: Wan | [[Category: Wan Y]] | ||