2v7o: Difference between revisions
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<StructureSection load='2v7o' size='340' side='right'caption='[[2v7o]], [[Resolution|resolution]] 2.25Å' scene=''> | <StructureSection load='2v7o' size='340' side='right'caption='[[2v7o]], [[Resolution|resolution]] 2.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2v7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2v7o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V7O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V7O FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DRN:BISINDOLYLMALEIMIDE+IX'>DRN</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7o OCA], [https://pdbe.org/2v7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7o RCSB], [https://www.ebi.ac.uk/pdbsum/2v7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7o ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v7o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v7o OCA], [https://pdbe.org/2v7o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v7o RCSB], [https://www.ebi.ac.uk/pdbsum/2v7o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v7o ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/KCC2G_HUMAN KCC2G_HUMAN] The disease may be caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/KCC2G_HUMAN KCC2G_HUMAN] Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity (PubMed:16690701). In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin (PubMed:16690701). In the central nervous system, it is involved in the regulation of neurite formation and arborization (PubMed:30184290). It may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In response to interferon-gamma (IFN-gamma) stimulation, catalyzes phosphorylation of STAT1, stimulating the JAK-STAT signaling pathway (By similarity).[UniProtKB:Q923T9]<ref>PMID:16690701</ref> <ref>PMID:30184290</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Burgess-Brown | [[Category: Burgess-Brown N]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Fedorov O]] | ||
[[Category: Fedorov | [[Category: Knapp S]] | ||
[[Category: Knapp | [[Category: Pike ACW]] | ||
[[Category: Pike | [[Category: Pilka ES]] | ||
[[Category: Pilka | [[Category: Rellos P]] | ||
[[Category: Rellos | [[Category: Shrestha L]] | ||
[[Category: Shrestha | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Ugochukwu E]] | ||
[[Category: Ugochukwu | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Von Delft F]] | ||
[[Category: | |||