2jgc: Difference between revisions

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 <StructureSection load='2jgc' size='340' side='right'caption='[[2jgc]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2jgc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2jgc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JGC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JGC FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2jgb|2jgb]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jgc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jgc OCA], [https://pdbe.org/2jgc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jgc RCSB], [https://www.ebi.ac.uk/pdbsum/2jgc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jgc ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/4EBP1_HUMAN 4EBP1_HUMAN]] Regulates eIF4E activity by preventing its assembly into the eIF4F complex. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.<ref>PMID:7935836</ref>
+[https://www.uniprot.org/uniprot/IF4E2_HUMAN IF4E2_HUMAN] Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:9582349, PubMed:17368478, PubMed:25624349). Acts as a repressor of translation initiation (PubMed:22751931). In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).[UniProtKB:Q8BMB3]<ref>PMID:17368478</ref> <ref>PMID:22751931</ref> <ref>PMID:25624349</ref> <ref>PMID:9582349</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Cameron, A D]]
+[[Category: Cameron AD]]
-[[Category: Knapp, S]]
+[[Category: Knapp S]]
-[[Category: Rosettani, P]]
+[[Category: Rosettani P]]
-[[Category: Rusconi, L]]
+[[Category: Rusconi L]]
-[[Category: Vismara, M G]]
+[[Category: Vismara MG]]
-[[Category: Acetylation]]
-[[Category: Cap-binding]]
-[[Category: Eif4e]]
-[[Category: Eukaryotic initiation factor]]
-[[Category: Initiation factor]]
-[[Category: Phosphorylation]]
-[[Category: Protein biosynthesis]]
-[[Category: Protein synthesis inhibitor]]
-[[Category: Rna-binding]]
-[[Category: Translation]]
-[[Category: Translation regulation]]