2j7y: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 3: / Line 3: @@
 <StructureSection load='2j7y' size='340' side='right'caption='[[2j7y]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2j7y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7Y FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2j7y]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J7Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J7Y FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=E3O:(16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL'>E3O</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1hj1|1hj1]], [[1qkn|1qkn]], [[1v95|1v95]], [[2j7x|2j7x]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BCT:BICARBONATE+ION'>BCT</scene>, <scene name='pdbligand=E3O:(16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL'>E3O</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j7y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j7y OCA], [https://pdbe.org/2j7y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j7y RCSB], [https://www.ebi.ac.uk/pdbsum/2j7y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j7y ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/ESR2_RAT ESR2_RAT]] Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER-alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action. [[https://www.uniprot.org/uniprot/NCOA5_HUMAN NCOA5_HUMAN]] Nuclear receptor coregulator that can have both coactivator and corepressor functions. Interacts with nuclear receptors for steroids (ESR1 and ESR2) independently of the steroid binding domain (AF-2) of the ESR receptors, and with the orphan nuclear receptor NR1D2. Involved in the coactivation of nuclear steroid receptors (ER) as well as the corepression of MYC in response to 17-beta-estradiol (E2).<ref>PMID:15073177</ref>
+[https://www.uniprot.org/uniprot/ESR2_RAT ESR2_RAT] Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER-alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 23: / Line 23: @@
 ==See Also==
 *[[Estrogen receptor 3D structures|Estrogen receptor 3D structures]]
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Bonn, T]]
+[[Category: Rattus norvegicus]]
-[[Category: Brzozowski, A M]]
+[[Category: Bonn T]]
-[[Category: Carlquist, M]]
+[[Category: Brzozowski AM]]
-[[Category: Engstrom, O]]
+[[Category: Carlquist M]]
-[[Category: Gustaffson, J A]]
+[[Category: Engstrom O]]
-[[Category: Hubbard, R E]]
+[[Category: Gustaffson J-A]]
-[[Category: Ljunggren, J]]
+[[Category: Hubbard RE]]
-[[Category: Pike, A C.W]]
+[[Category: Ljunggren J]]
-[[Category: Thorsell, A G]]
+[[Category: Pike ACW]]
-[[Category: Walton, J]]
+[[Category: Thorsell A-G]]
-[[Category: Activator]]
+[[Category: Walton J]]
-[[Category: Coactivator]]
-[[Category: Corepressor]]
-[[Category: Dna-binding]]
-[[Category: Glycoprotein]]
-[[Category: Lipid-binding]]
-[[Category: Metal-binding]]
-[[Category: Nuclear protein]]
-[[Category: Nuclear receptor]]
-[[Category: Phosphorylation]]
-[[Category: Receptor]]
-[[Category: Repressor]]
-[[Category: Steroid-binding]]
-[[Category: Transcription]]
-[[Category: Transcription factor]]
-[[Category: Transcription regulation]]
-[[Category: Zinc-finger]]