1oxb: Difference between revisions

Revision as of 04:23, 3 May 2008

Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)

OverviewOverview

In Saccharomyces cerevisiae, a branched multistep phosphorelay signaling pathway regulates cellular adaptation to hyperosmotic stress. YPD1 functions as a histidine-phosphorylated protein intermediate required for phosphoryl group transfer from a membrane-bound sensor histidine kinase (SLN1) to two distinct response regulator proteins (SSK1 and SKN7). These four proteins are evolutionarily related to the well-characterized "two-component" regulatory proteins from bacteria. Although structural information is available for many two-component signaling proteins, there are very few examples of complexes between interacting phosphorelay partners. Here we report the first crystal structure of a prototypical monomeric histidine-containing phosphotransfer (HPt) protein YPD1 in complex with its upstream phosphodonor, the response regulator domain associated with SLN1.

About this StructureAbout this Structure

1OXB is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

The yeast YPD1/SLN1 complex: insights into molecular recognition in two-component signaling systems., Xu Q, Porter SW, West AH, Structure. 2003 Dec;11(12):1569-81. PMID:14656441 Page seeded by OCA on Sat May 3 04:23:32 2008

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OCA

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 [[Image:1oxb.jpg|left|200px]]
- {{Structure
+<!--
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+The line below this paragraph, containing "STRUCTURE_1oxb", creates the "Structure Box" on the page.
-|SITE=
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-|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
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-|GENE= YPD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae]), SLN1 OR YPD2 OR YIL147C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
+-->
-|DOMAIN=
+{{STRUCTURE_1oxb|  PDB=1oxb  |  SCENE=  }}
-|RELATEDENTRY=[[1qsp|1QSP]], [[1oxk|1OXK]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oxb OCA], [http://www.ebi.ac.uk/pdbsum/1oxb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oxb RCSB]</span>
-}}
 '''Complex between YPD1 and SLN1 response regulator domain in space group P2(1)2(1)2(1)'''
@@ Line 28: / Line 25: @@
 [[Category: West, A H.]]
 [[Category: Xu, Q.]]
-[[Category: histidine-containing phosphotransfer protein]]
+[[Category: Histidine-containing phosphotransfer protein]]
-[[Category: hpt domain]]
+[[Category: Hpt domain]]
-[[Category: phosphorelay protein]]
+[[Category: Phosphorelay protein]]
-[[Category: response regulator]]
+[[Category: Response regulator]]
-[[Category: sln1p]]
+[[Category: Sln1p]]
-[[Category: two-component signaling protein]]
+[[Category: Two-component signaling protein]]
-[[Category: ypd1p]]
+[[Category: Ypd1p]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:23:32 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:51:43 2008''