2cmo: Difference between revisions

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 <StructureSection load='2cmo' size='340' side='right'caption='[[2cmo]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMO FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2cmo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CMO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CMO FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1ftj|1ftj]], [[1ftk|1ftk]], [[1ftl|1ftl]], [[1ftm|1ftm]], [[1fto|1fto]], [[1fw0|1fw0]], [[1gr2|1gr2]], [[1lb8|1lb8]], [[1lb9|1lb9]], [[1lbb|1lbb]], [[1lbc|1lbc]], [[1m5b|1m5b]], [[1m5c|1m5c]], [[1m5d|1m5d]], [[1m5e|1m5e]], [[1m5f|1m5f]], [[1mm6|1mm6]], [[1mm7|1mm7]], [[1mqd|1mqd]], [[1mqg|1mqg]], [[1mqh|1mqh]], [[1mqi|1mqi]], [[1mqj|1mqj]], [[1ms7|1ms7]], [[1mxu|1mxu]], [[1mxv|1mxv]], [[1mxw|1mxw]], [[1mxx|1mxx]], [[1mxy|1mxy]], [[1mxz|1mxz]], [[1my0|1my0]], [[1my1|1my1]], [[1my2|1my2]], [[1my3|1my3]], [[1my4|1my4]], [[1n0t|1n0t]], [[1nnk|1nnk]], [[1nnp|1nnp]], [[1p1n|1p1n]], [[1p1o|1p1o]], [[1p1q|1p1q]], [[1p1u|1p1u]], [[1p1w|1p1w]], [[1syh|1syh]], [[1syi|1syi]], [[1wvj|1wvj]], [[1xhy|1xhy]], [[2aix|2aix]], [[2al4|2al4]], [[2al5|2al5]], [[2anj|2anj]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=M1L:2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC+ACID'>M1L</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cmo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cmo OCA], [https://pdbe.org/2cmo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cmo RCSB], [https://www.ebi.ac.uk/pdbsum/2cmo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cmo ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/GRIA2_RAT GRIA2_RAT] Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.<ref>PMID:9351977</ref> <ref>PMID:19265014</ref> <ref>PMID:21172611</ref> <ref>PMID:12501192</ref> <ref>PMID:12015593</ref> <ref>PMID:12872125</ref> <ref>PMID:12730367</ref> <ref>PMID:16192394</ref> <ref>PMID:15591246</ref> <ref>PMID:17018279</ref> <ref>PMID:16483599</ref> <ref>PMID:19946266</ref> <ref>PMID:21317873</ref> <ref>PMID:21846932</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 __TOC__
 </StructureSection>
-[[Category: Buffalo rat]]
 [[Category: Large Structures]]
-[[Category: Gajhede, M]]
+[[Category: Rattus norvegicus]]
-[[Category: Greenwood, J R]]
+[[Category: Gajhede M]]
-[[Category: Kasper, C]]
+[[Category: Greenwood JR]]
-[[Category: Kastrup, J S]]
+[[Category: Kasper C]]
-[[Category: Kristensen, A S]]
+[[Category: Kastrup JS]]
-[[Category: Liljefors, T]]
+[[Category: Kristensen AS]]
-[[Category: Mirza, O]]
+[[Category: Liljefors T]]
-[[Category: Olsen, L]]
+[[Category: Mirza O]]
-[[Category: Pickering, D S]]
+[[Category: Olsen L]]
-[[Category: Schousboe, A]]
+[[Category: Pickering DS]]
-[[Category: Sigurskjold, B W]]
+[[Category: Schousboe A]]
-[[Category: Watjen, F]]
+[[Category: Sigurskjold BW]]
-[[Category: Alternative splicing]]
+[[Category: Watjen F]]
-[[Category: Glycoprotein]]
-[[Category: Ion channel]]
-[[Category: Ion transport]]
-[[Category: Ionic channel]]
-[[Category: Lipoprotein]]
-[[Category: Membrane]]
-[[Category: Palmitate]]
-[[Category: Postsynaptic membrane]]
-[[Category: Receptor]]
-[[Category: Rna editing]]
-[[Category: Transmembrane]]
-[[Category: Transport]]