2cm9: Difference between revisions
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<StructureSection load='2cm9' size='340' side='right'caption='[[2cm9]], [[Resolution|resolution]] 2.30Å' scene=''> | <StructureSection load='2cm9' size='340' side='right'caption='[[2cm9]], [[Resolution|resolution]] 2.30Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2cm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2cm9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Ornithodoros_moubata Ornithodoros moubata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CM9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CM9 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=RCL:RICINOLEIC+ACID'>RCL</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm9 OCA], [https://pdbe.org/2cm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cm9 RCSB], [https://www.ebi.ac.uk/pdbsum/2cm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cm9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cm9 OCA], [https://pdbe.org/2cm9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cm9 RCSB], [https://www.ebi.ac.uk/pdbsum/2cm9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cm9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/C5I_ORNMO C5I_ORNMO] Bifunctional protein derived from blood-feeding ticks that specifically prevents complement-mediated C5 activation and acts as a scavenger for inflammatory modulators such as leukotriene B4 (LTB4). C5 and LTB4 binding activities are independent (PubMed:23625922). Inhibits classical and alternative pathways of complement activation by preventing the cleavage of complement C5 by both classical and alternative C5 convertases (PubMed:15699138) (Probable). Inhibits complement in all species tested (rabbit, rat, guinea pig, mouse, pig, and human) (PubMed:27018802). Also binds fatty acids such as palmitoleic acid and ricinoleic acid, as well as inflammatory modulators LTB4 (and presumably arachidonic acid (AA)) that may be sequestered to interfere with the host inflammatory response (PubMed:23625922). Does not bind to leukotriene C4 and thromboxane B2 (PubMed:23625922). In vivo, when tested on the mouse model of immune complex-induced acute lung injury (IC-ALI), shows a potent inhibitory activity of the pathology, equally dependent on both C5 inhibition and LTB4 binding for full activity (PubMed:23625922).<ref>PMID:15699138</ref> <ref>PMID:23625922</ref> <ref>PMID:27018802</ref> <ref>PMID:17445829</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ornithodoros moubata]] | [[Category: Ornithodoros moubata]] | ||
[[Category: | [[Category: Boland W]] | ||
[[Category: Johnson S]] | |||
[[Category: Lea SM]] | |||
[[Category: Lissina O]] | |||
[[Category: Nunn MA]] | |||
[[Category: Paesen GC]] | |||
[[Category: Roversi P]] | |||