2cb1: Difference between revisions

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<StructureSection load='2cb1' size='340' side='right'caption='[[2cb1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2cb1' size='340' side='right'caption='[[2cb1]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2cb1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thet8 Thet8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CB1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2cb1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CB1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CB1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/O-acetylhomoserine_aminocarboxypropyltransferase O-acetylhomoserine aminocarboxypropyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.49 2.5.1.49] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cb1 OCA], [https://pdbe.org/2cb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cb1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cb1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cb1 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cb1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cb1 OCA], [https://pdbe.org/2cb1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cb1 RCSB], [https://www.ebi.ac.uk/pdbsum/2cb1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cb1 ProSAT], [https://www.topsan.org/Proteins/RSGI/2cb1 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/METY2_THET8 METY2_THET8] Catalyzes the conversion of O-acetyl-L-homoserine (OAH) into homocysteine in the methionine biosynthesis pathway. Has weak activity with O-acetyl-L-serine, O-phospho-L-serine, L-serine, O-succinyl-L-homoserine and L-homoserine. Shows a very low CTT gamma-synthase activity.<ref>PMID:15215603</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cb1 ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2cb1 ConSurf].
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== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: O-acetylhomoserine aminocarboxypropyltransferase]]
[[Category: Thermus thermophilus HB8]]
[[Category: Thet8]]
[[Category: Agari Y]]
[[Category: Agari, Y]]
[[Category: Ebihara A]]
[[Category: Ebihara, A]]
[[Category: Imagawa T]]
[[Category: Imagawa, T]]
[[Category: Kanagawa M]]
[[Category: Kanagawa, M]]
[[Category: Kuramitsu S]]
[[Category: Kuramitsu, S]]
[[Category: Kuroishi C]]
[[Category: Kuroishi, C]]
[[Category: Nakagawa N]]
[[Category: Nakagawa, N]]
[[Category: Tsuge H]]
[[Category: Tsuge, H]]
[[Category: Utsunomiya H]]
[[Category: Utsunomiya, H]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: Homoserine]]
[[Category: Lyase]]
[[Category: Plp enzyme]]
[[Category: Structural genomic]]
[[Category: Rsgi]]
[[Category: Sulfhydrylase]]

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