2c23: Difference between revisions
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<StructureSection load='2c23' size='340' side='right'caption='[[2c23]], [[Resolution|resolution]] 2.65Å' scene=''> | <StructureSection load='2c23' size='340' side='right'caption='[[2c23]], [[Resolution|resolution]] 2.65Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2c23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2c23]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C23 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C23 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c23 OCA], [https://pdbe.org/2c23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c23 RCSB], [https://www.ebi.ac.uk/pdbsum/2c23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c23 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c23 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c23 OCA], [https://pdbe.org/2c23 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c23 RCSB], [https://www.ebi.ac.uk/pdbsum/2c23 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c23 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/1433B_HUMAN 1433B_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2.<ref>PMID:17717073</ref> <ref>PMID:19592491</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Pseudomonas aeruginosa]] | ||
[[Category: Doyle | [[Category: Arrowsmith C]] | ||
[[Category: Edwards | [[Category: Doyle DA]] | ||
[[Category: Elkins | [[Category: Edwards A]] | ||
[[Category: Schoch | [[Category: Elkins JM]] | ||
[[Category: Sundstrom | [[Category: Schoch GA]] | ||
[[Category: Yang | [[Category: Sundstrom M]] | ||
[[Category: Yang X]] | |||