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2bu8: Difference between revisions

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<StructureSection load='2bu8' size='340' side='right'caption='[[2bu8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='2bu8' size='340' side='right'caption='[[2bu8]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2bu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BU8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2bu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BU8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TF4:DICHLORO-ACETIC+ACID'>TF4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2btz|2btz]], [[2bu2|2bu2]], [[2bu5|2bu5]], [[2bu6|2bu6]], [[2bu7|2bu7]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=TF4:DICHLORO-ACETIC+ACID'>TF4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/[Pyruvate_dehydrogenase_(acetyl-transferring)]_kinase [Pyruvate dehydrogenase (acetyl-transferring)] kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.2 2.7.11.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bu8 OCA], [https://pdbe.org/2bu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bu8 RCSB], [https://www.ebi.ac.uk/pdbsum/2bu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bu8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bu8 OCA], [https://pdbe.org/2bu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bu8 RCSB], [https://www.ebi.ac.uk/pdbsum/2bu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bu8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDK2_HUMAN PDK2_HUMAN] Serine/threonine kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis.<ref>PMID:7499431</ref> <ref>PMID:9787110</ref> <ref>PMID:17222789</ref> <ref>PMID:19833728</ref> <ref>PMID:21283817</ref> <ref>PMID:22123926</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Brown, D G]]
[[Category: Brown DG]]
[[Category: Bungay, P J]]
[[Category: Bungay PJ]]
[[Category: Kasten, S A]]
[[Category: Kasten SA]]
[[Category: Knoechel, T R]]
[[Category: Knoechel TR]]
[[Category: Phillips, C]]
[[Category: Phillips C]]
[[Category: Robinson, C M]]
[[Category: Robinson CM]]
[[Category: Roche, T E]]
[[Category: Roche TE]]
[[Category: Taylor, W]]
[[Category: Taylor W]]
[[Category: Tucker, A D]]
[[Category: Tucker AD]]
[[Category: Pyruvate dehydrogenase kinase 2 ghkl motif regulation]]
[[Category: Transferase]]

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