1otc: Difference between revisions

Revision as of 04:15, 3 May 2008

THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA

OverviewOverview

Telomeres are specialized protein-DNA complexes that compose the ends of eukaryotic chromosomes. Telomeres protect chromosome termini from degradation and recombination and act together with telomerase to ensure complete genome replication. We have determined the crystal structure of the two-subunit Oxytricha nova telomere end binding protein (OnTEBP) complexed with single strand telomeric DNA at 2.8 A resolution. The structure reveals four oligonucleotide/oligosaccharide-binding folds, three of which form a deep cleft that binds the ssDNA, and a fourth that forms an unusual protein-protein interaction between the alpha and beta subunits. This structure provides a molecular description of how the two subunits of OnTEBP recognize and bind ssDNA to form a sequence-specific, telomeric nucleoprotein complex that caps the very 3' ends of chromosomes.

About this StructureAbout this Structure

1OTC is a Protein complex structure of sequences from Sterkiella nova. Full crystallographic information is available from OCA.

ReferenceReference

Crystal structure of the Oxytricha nova telomere end binding protein complexed with single strand DNA., Horvath MP, Schweiker VL, Bevilacqua JM, Ruggles JA, Schultz SC, Cell. 1998 Dec 23;95(7):963-74. PMID:9875850 Page seeded by OCA on Sat May 3 04:15:35 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
 [[Image:1otc.gif|left|200px]]
- {{Structure
+<!--
-|PDB= 1otc |SIZE=350|CAPTION= <scene name='initialview01'>1otc</scene>, resolution 2.80&Aring;
+The line below this paragraph, containing "STRUCTURE_1otc", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=DG:2&#39;-DEOXYGUANOSINE-5&#39;-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DT:THYMIDINE-5&#39;-MONOPHOSPHATE'>DT</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= MAC-56A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=200597 Sterkiella nova]), MAC-41A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=200597 Sterkiella nova])
+-->
-|DOMAIN=
+{{STRUCTURE_1otc|  PDB=1otc  |  SCENE=  }}
-|RELATEDENTRY=
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1otc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1otc OCA], [http://www.ebi.ac.uk/pdbsum/1otc PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1otc RCSB]</span>
-}}
 '''THE O. NOVA TELOMERE END BINDING PROTEIN COMPLEXED WITH SINGLE STRAND DNA'''
@@ Line 30: / Line 27: @@
 [[Category: Schultz, S C.]]
 [[Category: Schweiker, V L.]]
-[[Category: ob fold]]
+[[Category: Ob fold]]
-[[Category: oligonucleotide and oligosaccharide binding fold]]
+[[Category: Oligonucleotide and oligosaccharide binding fold]]
-[[Category: protein dna interaction]]
+[[Category: Protein dna interaction]]
-[[Category: protein protein interaction]]
+[[Category: Protein protein interaction]]
-[[Category: single strand dna binding protein]]
+[[Category: Single strand dna binding protein]]
-[[Category: telomere]]
+[[Category: Telomere]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:15:35 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:50:03 2008''