8f47: Difference between revisions
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==Crystal structure of VACV D13 in complex with STK69439== | |||
<StructureSection load='8f47' size='340' side='right'caption='[[8f47]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8f47]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus Vaccinia virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8F47 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8F47 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=XDF:6,8-dimethoxy-2-methylquinolin-4-amine'>XDF</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8f47 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8f47 OCA], [https://pdbe.org/8f47 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8f47 RCSB], [https://www.ebi.ac.uk/pdbsum/8f47 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8f47 ProSAT]</span></td></tr> | ||
[[Category: Coulibaly | </table> | ||
[[Category: Subedi | == Function == | ||
[https://www.uniprot.org/uniprot/D13_VACCW D13_VACCW] Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Vaccinia virus]] | |||
[[Category: Coulibaly F]] | |||
[[Category: Garriga D]] | |||
[[Category: Subedi BP]] | |||
Latest revision as of 14:39, 13 December 2023
Crystal structure of VACV D13 in complex with STK69439Crystal structure of VACV D13 in complex with STK69439
Structural highlights
FunctionD13_VACCW Scaffold protein which forms a transitory spherical honeycomb lattice providing curvature and rigidity to the convex membrane of crescent and immature virions (IV). This association occurs concomitantly with viral membrane formation. Targeted by the drug rifampicin, which prevents the formation of this lattice, and hence virus morphogenesis. In the presence of rifampicin, irregularly shaped membranes that lack the honeycomb layer accumulate around areas of electron-dense viroplasm. This layer is lost from virions during maturation from IV to mature virion (MV), through the proteolysis of A17 N-terminus. |
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