1srb: Difference between revisions
No edit summary |
No edit summary |
||
Line 1: | Line 1: | ||
==CONFORMATIONAL STUDIES ON SRTB, A NON-SELECTIVE ENDOTHELIN RECEPTOR AGONIST, AND ON IRL 1620, AN ETB RECEPTOR SPECIFIC AGONIST== | ==CONFORMATIONAL STUDIES ON SRTB, A NON-SELECTIVE ENDOTHELIN RECEPTOR AGONIST, AND ON IRL 1620, AN ETB RECEPTOR SPECIFIC AGONIST== | ||
<StructureSection load='1srb' size='340' side='right'caption='[[1srb | <StructureSection load='1srb' size='340' side='right'caption='[[1srb]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1srb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1srb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Atractaspis_andersonii Atractaspis andersonii]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SRB FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1srb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1srb OCA], [https://pdbe.org/1srb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1srb RCSB], [https://www.ebi.ac.uk/pdbsum/1srb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1srb ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1srb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1srb OCA], [https://pdbe.org/1srb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1srb RCSB], [https://www.ebi.ac.uk/pdbsum/1srb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1srb ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/SRTX_ATREN SRTX_ATREN] Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm.<ref>PMID:21889567</ref> Sarafotoxin-B: vasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm (By similarity). Displays high agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the picomolar range) and endothelin-1 receptor (EDNRA) (lower affinities) (PubMed:21889567).<ref>PMID:21889567</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
Line 21: | Line 22: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Atractaspis andersonii]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Atkins | [[Category: Atkins AR]] | ||
[[Category: Smith | [[Category: Smith R]] | ||