8wb0: Difference between revisions

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'''Unreleased structure'''


The entry 8wb0 is ON HOLD  until Paper Publication
==De novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSS==
 
<StructureSection load='8wb0' size='340' side='right'caption='[[8wb0]], [[Resolution|resolution]] 2.94&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8wb0]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WB0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WB0 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.94&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=G2L:3-O-METHYOXYETHYL-GUANOSINE-5-MONOPHOSPHATE'>G2L</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=ILX:4,5-DIHYDROXYISOLEUCINE'>ILX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PRD_000201:Alpha-Amanitin'>PRD_000201</scene>, <scene name='pdbligand=TRX:6-HYDROXYTRYPTOPHAN'>TRX</scene>, <scene name='pdbligand=W0F:[[(2~{S},3~{R},4~{S},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3-methoxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>W0F</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wb0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wb0 OCA], [https://pdbe.org/8wb0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wb0 RCSB], [https://www.ebi.ac.uk/pdbsum/8wb0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wb0 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AAMAT_AMAPH AAMAT_AMAPH] Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:4865716, PubMed:363352, PubMed:7642577, PubMed:8702941).<ref>PMID:363352</ref> <ref>PMID:4865716</ref> <ref>PMID:7642577</ref> <ref>PMID:8702941</ref> <ref>PMID:24613547</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Amanita phalloides]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Sus scrofa]]
[[Category: Synthetic construct]]
[[Category: Chen X]]
[[Category: Li W]]
[[Category: Liu W]]
[[Category: Qu X]]
[[Category: Ren Y]]
[[Category: Wang Q]]
[[Category: Wang X]]
[[Category: Xu Y]]

Revision as of 11:07, 6 December 2023

De novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSSDe novo transcribing complex 17 (TC17), the early elongation complex with Pol II positioned 17nt downstream of TSS

Structural highlights

8wb0 is a 10 chain structure with sequence from Amanita phalloides, Homo sapiens, Sus scrofa and Synthetic construct. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 2.94Å
Ligands:, , , , , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

AAMAT_AMAPH Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters (PubMed:4865716, PubMed:363352, PubMed:7642577, PubMed:8702941).[1] [2] [3] [4] [5]

References

  1. ↑ Wieland T, Faulstich H. Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms. CRC Crit Rev Biochem. 1978 Dec;5(3):185-260. PMID:363352
  2. ↑ Wieland T. Poisonous principles of mushrooms of the genus Amanita. Four-carbon amines acting on the central nervous system and cell-destroying cyclic peptides are produced. Science. 1968 Mar 1;159(3818):946-52. PMID:4865716
  3. ↑ Chafin DR, Guo H, Price DH. Action of alpha-amanitin during pyrophosphorolysis and elongation by RNA polymerase II. J Biol Chem. 1995 Aug 11;270(32):19114-9. PMID:7642577
  4. ↑ Rudd MD, Luse DS. Amanitin greatly reduces the rate of transcription by RNA polymerase II ternary complexes but fails to inhibit some transcript cleavage modes. J Biol Chem. 1996 Aug 30;271(35):21549-58. PMID:8702941
  5. ↑ Li P, Deng W, Li T. The molecular diversity of toxin gene families in lethal Amanita mushrooms. Toxicon. 2014 Jun;83:59-68. doi: 10.1016/j.toxicon.2014.02.020. Epub 2014 Mar 5. PMID:24613547 doi:http://dx.doi.org/10.1016/j.toxicon.2014.02.020

8wb0, resolution 2.94Å

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