Thymidine kinase: Difference between revisions
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<StructureSection load='2j9r' size='350' side='right' caption='Thymidine kinase complex with thymidine, phosphate and Zn+2 ion (grey) (PDB entry [[2j94]])' scene='45/455455/Cv/1'> | <StructureSection load='2j9r' size='350' side='right' caption='Thymidine kinase complex with thymidine, phosphate and Zn+2 ion (grey) (PDB entry [[2j94]])' scene='45/455455/Cv/1'> | ||
== Function == | == Function == | ||
'''Thymidine kinase''' or '''deoxyribonucleoside kinase''' (TK) catalyzes the conversion of deoxythymidine (THM) to deoxythymidine 5’-phosphate (THMP) with the conversion of ATP to ADP. TK has an important role in the synthesis of DNA. It is required for the action of many antiviral drugs. Higher organisms have 2 isozymes. '''TK1''' is cell cycle-dependent while '''TK2''' <ref>PMID:18459168</ref>is found in the mitochondria and is cell cycle-independent. TK undergoes feed-back regulation by thymidine triphosphate (TTP). Adenosyl-thymidyl-tetraphosphate (TP4A) is a bisubstrate inhibitor of TK. For more details see [[Herpes Simplex Virus Thymidine Kinase]] and [[Aciclovir]]. | '''Thymidine kinase''' or '''deoxyribonucleoside kinase''' (TK) catalyzes the conversion of deoxythymidine (THM) to deoxythymidine 5’-phosphate (THMP) with the conversion of ATP to ADP. TK has an important role in the synthesis of DNA. It is required for the action of many antiviral drugs. Higher organisms have 2 isozymes. '''TK1''' is cell cycle-dependent while '''TK2''' <ref>PMID:18459168</ref>is found in the mitochondria and is cell cycle-independent. TK undergoes feed-back regulation by thymidine triphosphate (TTP). Adenosyl-thymidyl-tetraphosphate (TP4A) is a bisubstrate inhibitor of TK. For more details see [[Herpes Simplex Virus Thymidine Kinase]] and drug [[Aciclovir]]. | ||
== Relevance == | == Relevance == | ||