1ooh: Difference between revisions

Revision as of 04:06, 3 May 2008

Complex of Drosophila odorant binding protein LUSH with butanol

OverviewOverview

We have solved the high-resolution crystal structures of the Drosophila melanogaster alcohol-binding protein LUSH in complex with a series of short-chain n-alcohols. LUSH is the first known nonenzyme protein with a defined in vivo alcohol-binding function. The structure of LUSH reveals a set of molecular interactions that define a specific alcohol-binding site. A group of amino acids, Thr57, Ser52 and Thr48, form a network of concerted hydrogen bonds between the protein and the alcohol that provides a structural motif to increase alcohol-binding affinity at this site. This motif seems to be conserved in a number of mammalian ligand-gated ion channels that are directly implicated in the pharmacological effects of alcohol. Further, these sequences are found in regions of ion channels that are known to confer alcohol sensitivity. We suggest that the alcohol-binding site in LUSH represents a general model for alcohol-binding sites in proteins.

About this StructureAbout this Structure

1OOH is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

ReferenceReference

Structure of a specific alcohol-binding site defined by the odorant binding protein LUSH from Drosophila melanogaster., Kruse SW, Zhao R, Smith DP, Jones DN, Nat Struct Biol. 2003 Sep;10(9):694-700. Epub 2003 Jul 27. PMID:12881720 Page seeded by OCA on Sat May 3 04:06:10 2008

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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 [[Image:1ooh.jpg|left|200px]]
- {{Structure
+<!--
-|PDB= 1ooh |SIZE=350|CAPTION= <scene name='initialview01'>1ooh</scene>, resolution 1.25&Aring;
+The line below this paragraph, containing "STRUCTURE_1ooh", creates the "Structure Box" on the page.
-|SITE=
+You may change the PDB parameter (which sets the PDB file loaded into the applet)
-|LIGAND= <scene name='pdbligand=1BO:1-BUTANOL'>1BO</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>
+or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-|ACTIVITY=
+or leave the SCENE parameter empty for the default display.
-|GENE= lush ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7227 Drosophila melanogaster])
+-->
-|DOMAIN=
+{{STRUCTURE_1ooh|  PDB=1ooh  |  SCENE=  }}
-|RELATEDENTRY=[[1oof|1OOF]], [[1oog|1OOG]]
-|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ooh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ooh OCA], [http://www.ebi.ac.uk/pdbsum/1ooh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1ooh RCSB]</span>
-}}
 '''Complex of Drosophila odorant binding protein LUSH with butanol'''
@@ Line 29: / Line 26: @@
 [[Category: Smith, D P.]]
 [[Category: Zhao, R.]]
-[[Category: alcohol]]
+[[Category: Alcohol]]
-[[Category: lush]]
+[[Category: Lush]]
-[[Category: odorant binding]]
+[[Category: Odorant binding]]
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 04:06:10 2008''
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:48:11 2008''