1hp9: Difference between revisions
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==kappa-Hefutoxins: a novel Class of Potassium Channel Toxins from Scorpion venom== | ==kappa-Hefutoxins: a novel Class of Potassium Channel Toxins from Scorpion venom== | ||
<StructureSection load='1hp9' size='340' side='right'caption='[[1hp9 | <StructureSection load='1hp9' size='340' side='right'caption='[[1hp9]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1hp9]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HP9 FirstGlance]. <br> | <table><tr><td colspan='2'>[[1hp9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Chersonesometrus_fulvipes Chersonesometrus fulvipes]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HP9 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp9 OCA], [https://pdbe.org/1hp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hp9 RCSB], [https://www.ebi.ac.uk/pdbsum/1hp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hp9 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hp9 OCA], [https://pdbe.org/1hp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hp9 RCSB], [https://www.ebi.ac.uk/pdbsum/1hp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hp9 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KKX11_CHEFU KKX11_CHEFU] Shows weak blocking activity on voltage-gated potassium channels Kv10.1/KCNH1/EAG1 (IC(50)=26 uM), Kv1.2/KCNA2 (Kd=150 uM), Kv1.3/KCNA3 (Kd=40 uM), Kv1.6/KCNA3 (16.6% inhibition at 40 uM toxin) (PubMed:12034709, PubMed:23726856, PubMed:27578329). The block is dose-dependent, voltage-independent, and reversible (PubMed:12034709). Also shows a weak inhibitory activity on the plant pathogen F.culmorum growth (IC(50)=18.8-37.7 uM) (PubMed:27578329).<ref>PMID:12034709</ref> <ref>PMID:23726856</ref> <ref>PMID:27578329</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Chersonesometrus fulvipes]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bowie | [[Category: Bowie JH]] | ||
[[Category: | [[Category: Brian Chia CS]] | ||
[[Category: | [[Category: Cheng B]] | ||
[[Category: Gopalakrishnakone | [[Category: Gopalakrishnakone P]] | ||
[[Category: Huys | [[Category: Huys I]] | ||
[[Category: Kini | [[Category: Kini RM]] | ||
[[Category: Kumar | [[Category: Kumar TKS]] | ||
[[Category: Ranganathan | [[Category: Ranganathan S]] | ||
[[Category: Sasaki | [[Category: Sasaki T]] | ||
[[Category: Sato | [[Category: Sato K]] | ||
[[Category: Sivaraja | [[Category: Sivaraja V]] | ||
[[Category: Srinivasan | [[Category: Srinivasan KN]] | ||
[[Category: Tytgat | [[Category: Tytgat J]] | ||
[[Category: Yu | [[Category: Yu C]] | ||