7w9h: Difference between revisions

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== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7w9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W9H FirstGlance]. <br>
<table><tr><td colspan='2'>[[7w9h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W9H FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w9h OCA], [https://pdbe.org/7w9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w9h RCSB], [https://www.ebi.ac.uk/pdbsum/7w9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w9h ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w9h OCA], [https://pdbe.org/7w9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w9h RCSB], [https://www.ebi.ac.uk/pdbsum/7w9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w9h ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[https://www.uniprot.org/uniprot/FLER_PSEAE FLER_PSEAE] Member of the two-component regulatory system FleS/FleR that regulates the expression of multiple genes involved in flagellar synthesis, adhesion, swarming, motility and antibiotic resistance (PubMed:7591148, PubMed:30877999, PubMed:8876537). May function as a transcriptional activator by direct binding to a cis-acting sequence upstream of the target genes (Probable).<ref>PMID:30877999</ref> <ref>PMID:7591148</ref> <ref>PMID:8876537</ref> <ref>PMID:7591148</ref>  
[https://www.uniprot.org/uniprot/FLER_PSEAE FLER_PSEAE] Member of the two-component regulatory system FleS/FleR that regulates the expression of multiple genes involved in flagellar synthesis, adhesion, swarming, motility and antibiotic resistance (PubMed:7591148, PubMed:30877999, PubMed:8876537). May function as a transcriptional activator by direct binding to a cis-acting sequence upstream of the target genes (Probable).<ref>PMID:30877999</ref> <ref>PMID:7591148</ref> <ref>PMID:8876537</ref> <ref>PMID:7591148</ref>  
==See Also==
*[[Response regulator 3D structure|Response regulator 3D structure]]
== References ==
== References ==
<references/>
<references/>

Latest revision as of 20:38, 29 November 2023

Crystal structure of the receiver domain of the transcription regulator FleR from Pseudomonas aeruginosaCrystal structure of the receiver domain of the transcription regulator FleR from Pseudomonas aeruginosa

Structural highlights

7w9h is a 2 chain structure with sequence from Pseudomonas aeruginosa PAO1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.28Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

FLER_PSEAE Member of the two-component regulatory system FleS/FleR that regulates the expression of multiple genes involved in flagellar synthesis, adhesion, swarming, motility and antibiotic resistance (PubMed:7591148, PubMed:30877999, PubMed:8876537). May function as a transcriptional activator by direct binding to a cis-acting sequence upstream of the target genes (Probable).[1] [2] [3] [4]

See Also

References

  1. ↑ Kollaran AM, Joge S, Kotian HS, Badal D, Prakash D, Mishra A, Varma M, Singh V. Context-Specific Requirement of Forty-Four Two-Component Loci in Pseudomonas aeruginosa Swarming. iScience. 2019 Mar 29;13:305-317. doi: 10.1016/j.isci.2019.02.028. Epub 2019 Mar , 1. PMID:30877999 doi:http://dx.doi.org/10.1016/j.isci.2019.02.028
  2. ↑ Ritchings BW, Almira EC, Lory S, Ramphal R. Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin. Infect Immun. 1995 Dec;63(12):4868-76. PMID:7591148
  3. ↑ Ramphal R, Arora SK, Ritchings BW. Recognition of mucin by the adhesin-flagellar system of Pseudomonas aeruginosa. Am J Respir Crit Care Med. 1996 Oct;154(4 Pt 2):S170-4. doi: , 10.1164/ajrccm/154.4_Pt_2.S170. PMID:8876537 doi:http://dx.doi.org/10.1164/ajrccm/154.4_Pt_2.S170
  4. ↑ Ritchings BW, Almira EC, Lory S, Ramphal R. Cloning and phenotypic characterization of fleS and fleR, new response regulators of Pseudomonas aeruginosa which regulate motility and adhesion to mucin. Infect Immun. 1995 Dec;63(12):4868-76. PMID:7591148

7w9h, resolution 2.28Å

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