7edo: Difference between revisions
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==== | ==First insight into marsupial MHC I peptide presentation: immune features of lower mammals paralleled with bats== | ||
<StructureSection load='7edo' size='340' side='right'caption='[[7edo]]' scene=''> | <StructureSection load='7edo' size='340' side='right'caption='[[7edo]], [[Resolution|resolution]] 2.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7edo]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Trichosurus_vulpecula Trichosurus vulpecula] and [https://en.wikipedia.org/wiki/Uncultured_virus Uncultured virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EDO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EDO FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7edo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7edo OCA], [https://pdbe.org/7edo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7edo RCSB], [https://www.ebi.ac.uk/pdbsum/7edo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7edo ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7edo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7edo OCA], [https://pdbe.org/7edo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7edo RCSB], [https://www.ebi.ac.uk/pdbsum/7edo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7edo ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/Q95IT0_TRIVU Q95IT0_TRIVU] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Marsupials are one of three major mammalian lineages that include the placental eutherians and the egg-laying monotremes. The marsupial brushtail possum is an important protected species in the Australian forest ecosystem. Molecules encoded by the MHC genes are essential mediators of adaptive immune responses in virus-host interactions. Yet, nothing is known about the peptide presentation features of any marsupial MHC class I (MHC I). This study identified a series of possum MHC I Trvu-UB*01:01 binding peptides derived from wobbly possum disease virus (WPDV), a lethal virus of both captive and feral possum populations, and unveiled the structure of marsupial peptide/MHC I complex. Notably, we found the two brushtail possum-specific insertions, the 3-aa Ile(52)Glu(53)Arg(54) and 1-aa Arg(154) insertions are located in the Trvu-UB*01:01 peptide binding groove (PBG). The 3-aa insertion plays a pivotal role in maintaining the stability of the N terminus of Trvu-UB*01:01 PBG. This aspect of marsupial PBG is unexpectedly similar to the bat MHC I Ptal-N*01:01 and is shared with lower vertebrates from elasmobranch to monotreme, indicating an evolution hotspot that may have emerged from the pathogen-host interactions. Residue Arg(154) insertion, located in the alpha2 helix, is available for TCR recognition, and it has a particular influence on promoting the anchoring of peptide WPDV-12. These findings add significantly to our understanding of adaptive immunity in marsupials and its evolution in vertebrates. Our findings have the potential to impact the conservation of the protected species brushtail possum and other marsupial species. | |||
Peptide Presentations of Marsupial MHC Class I Visualize Immune Features of Lower Mammals Paralleled with Bats.,Wang P, Yue C, Liu K, Lu D, Liu S, Yao S, Li X, Su X, Ren K, Chai Y, Qi J, Zhao Y, Lou Y, Sun Z, Gao GF, Liu WJ J Immunol. 2021 Oct 15;207(8):2167-2178. doi: 10.4049/jimmunol.2100350. Epub 2021 , Sep 17. PMID:34535575<ref>PMID:34535575</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7edo" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]] | |||
*[[MHC 3D structures|MHC 3D structures]] | |||
*[[MHC I 3D structures|MHC I 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Trichosurus vulpecula]] | ||
[[Category: Uncultured virus]] | |||
[[Category: Chai Y]] | |||
[[Category: Gao GF]] | |||
[[Category: Liu KF]] | |||
[[Category: Liu S]] | |||
[[Category: Liu WJ]] | |||
[[Category: Lou YL]] | |||
[[Category: Lu D]] | |||
[[Category: Qi JX]] | |||
[[Category: Sun ZY]] | |||
[[Category: Wang PY]] | |||
[[Category: Yao SJ]] | |||
[[Category: Yue C]] | |||
Revision as of 19:51, 29 November 2023
First insight into marsupial MHC I peptide presentation: immune features of lower mammals paralleled with batsFirst insight into marsupial MHC I peptide presentation: immune features of lower mammals paralleled with bats
Structural highlights
FunctionPublication Abstract from PubMedMarsupials are one of three major mammalian lineages that include the placental eutherians and the egg-laying monotremes. The marsupial brushtail possum is an important protected species in the Australian forest ecosystem. Molecules encoded by the MHC genes are essential mediators of adaptive immune responses in virus-host interactions. Yet, nothing is known about the peptide presentation features of any marsupial MHC class I (MHC I). This study identified a series of possum MHC I Trvu-UB*01:01 binding peptides derived from wobbly possum disease virus (WPDV), a lethal virus of both captive and feral possum populations, and unveiled the structure of marsupial peptide/MHC I complex. Notably, we found the two brushtail possum-specific insertions, the 3-aa Ile(52)Glu(53)Arg(54) and 1-aa Arg(154) insertions are located in the Trvu-UB*01:01 peptide binding groove (PBG). The 3-aa insertion plays a pivotal role in maintaining the stability of the N terminus of Trvu-UB*01:01 PBG. This aspect of marsupial PBG is unexpectedly similar to the bat MHC I Ptal-N*01:01 and is shared with lower vertebrates from elasmobranch to monotreme, indicating an evolution hotspot that may have emerged from the pathogen-host interactions. Residue Arg(154) insertion, located in the alpha2 helix, is available for TCR recognition, and it has a particular influence on promoting the anchoring of peptide WPDV-12. These findings add significantly to our understanding of adaptive immunity in marsupials and its evolution in vertebrates. Our findings have the potential to impact the conservation of the protected species brushtail possum and other marsupial species. Peptide Presentations of Marsupial MHC Class I Visualize Immune Features of Lower Mammals Paralleled with Bats.,Wang P, Yue C, Liu K, Lu D, Liu S, Yao S, Li X, Su X, Ren K, Chai Y, Qi J, Zhao Y, Lou Y, Sun Z, Gao GF, Liu WJ J Immunol. 2021 Oct 15;207(8):2167-2178. doi: 10.4049/jimmunol.2100350. Epub 2021 , Sep 17. PMID:34535575[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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