7e6r: Difference between revisions

<table><tr><td colspan='2'>[[7e6r]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E6R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E6R FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e6r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e6r OCA], [https://pdbe.org/7e6r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e6r RCSB], [https://www.ebi.ac.uk/pdbsum/7e6r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e6r ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/R1A_CVHNL R1A_CVHNL]] The papain-like proteinase 1 (PLP1) and papain-like proteinase 2 (PLP2) are responsible for the cleavages located at the N-terminus of the replicase polyprotein. In addition, PLP2 possesses a deubiquitinating/deISGylating activity and processes both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains from cellular substrates. PLP2 also antagonizes innate immune induction of type I interferon by blocking the nuclear translocation of host IRF-3.  The main proteinase 3CL-PRO is responsible for the majority of cleavages as it cleaves the C-terminus of replicase polyprotein at 11 sites. Recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. Inhibited by the substrate-analog Cbz-Val-Asn-Ser-Thr-Leu-Gln-CMK. Also contains an ADP-ribose-1''-phosphate (ADRP)-binding function (By similarity).  Nsp7-nsp8 hexadecamer may possibly confer processivity to the polymerase, maybe by binding to dsRNA or by producing primers utilized by the latter (By similarity).  Nsp9 is a ssRNA-binding protein (By similarity).  

[[Category: Gao, H X]]

[[Category: Li, J]]

[[Category: Zhang, J]]

[[Category: Zhang, Y T]]

[[Category: Zhong, F L]]

[[Category: Zhou, X L]]

[[Category: Viral protein]]