7dzd: Difference between revisions
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==Crystal structure of uPA in complex with cleaved camostat== | ==Crystal structure of uPA in complex with cleaved camostat== | ||
<StructureSection load='7dzd' size='340' side='right'caption='[[7dzd]]' scene=''> | <StructureSection load='7dzd' size='340' side='right'caption='[[7dzd]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DZD FirstGlance]. <br> | <table><tr><td colspan='2'>[[7dzd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DZD FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dzd OCA], [https://pdbe.org/7dzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dzd RCSB], [https://www.ebi.ac.uk/pdbsum/7dzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dzd ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBS:4-GUANIDINOBENZOIC+ACID'>GBS</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dzd OCA], [https://pdbe.org/7dzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dzd RCSB], [https://www.ebi.ac.uk/pdbsum/7dzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dzd ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Defects in PLAU are the cause of Quebec platelet disorder (QPD) [MIM:[https://omim.org/entry/601709 601709]. QPD is an autosomal dominant bleeding disorder due to a gain-of-function defect in fibrinolysis. Although affected individuals do not exhibit systemic fibrinolysis, they show delayed onset bleeding after challenge, such as surgery. The hallmark of the disorder is markedly increased PLAU levels within platelets, which causes intraplatelet plasmin generation and secondary degradation of alpha-granule proteins.<ref>PMID:20007542</ref> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/UROK_HUMAN UROK_HUMAN] Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. | |||
==See Also== | |||
*[[Urokinase 3D Structures|Urokinase 3D Structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Huang MD]] | [[Category: Huang MD]] | ||
[[Category: Jiang LG]] | [[Category: Jiang LG]] | ||