7c88: Difference between revisions
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==== | ==Complex structure of JS003 and PD-L1== | ||
<StructureSection load='7c88' size='340' side='right'caption='[[7c88]]' scene=''> | <StructureSection load='7c88' size='340' side='right'caption='[[7c88]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7c88]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C88 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C88 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c88 OCA], [https://pdbe.org/7c88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c88 RCSB], [https://www.ebi.ac.uk/pdbsum/7c88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c88 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.997Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c88 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c88 OCA], [https://pdbe.org/7c88 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c88 RCSB], [https://www.ebi.ac.uk/pdbsum/7c88 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c88 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PD1L1_HUMAN PD1L1_HUMAN] Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.<ref>PMID:10581077</ref> <ref>PMID:11015443</ref> | |||
==See Also== | |||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Bi X]] | |||
[[Category: Chai Y]] | |||
[[Category: Qi J]] | |||
[[Category: Shi R]] | |||
[[Category: Tan S]] | |||
[[Category: Yan J]] | |||