7c7c: Difference between revisions
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<StructureSection load='7c7c' size='340' side='right'caption='[[7c7c]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='7c7c' size='340' side='right'caption='[[7c7c]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[7c7c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[7c7c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7C7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7C7C FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FK0:2-azanyl-9-[(4-bromanyl-2-fluoranyl-phenyl)methyl]-6-chloranyl-purin-8-ol'>FK0</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7c OCA], [https://pdbe.org/7c7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c7c RCSB], [https://www.ebi.ac.uk/pdbsum/7c7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7c7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7c7c OCA], [https://pdbe.org/7c7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7c7c RCSB], [https://www.ebi.ac.uk/pdbsum/7c7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7c7c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/TRAP1_HUMAN TRAP1_HUMAN] Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.<ref>PMID:23525905</ref> <ref>PMID:23564345</ref> <ref>PMID:23747254</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Kang | [[Category: Kang BH]] | ||
[[Category: Kang | [[Category: Kang S]] | ||
[[Category: Kim | [[Category: Kim D]] | ||
[[Category: Kim | [[Category: Kim SY]] | ||
[[Category: Lee | [[Category: Lee C]] | ||
[[Category: Park | [[Category: Park E]] | ||
[[Category: Yang | [[Category: Yang S]] | ||
[[Category: Yoon | [[Category: Yoon NG]] | ||