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==Chalcone synthase from Glycine max (L.) Merr (soybean)== | ==Chalcone synthase from Glycine max (L.) Merr (soybean)== | ||
<StructureSection load='7bus' size='340' side='right'caption='[[7bus]]' scene=''> | <StructureSection load='7bus' size='340' side='right'caption='[[7bus]], [[Resolution|resolution]] 2.52Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUS OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[7bus]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Glycine_max Glycine max]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BUS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BUS FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.52Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene>, <scene name='pdbligand=SME:METHIONINE+SULFOXIDE'>SME</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bus FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bus OCA], [https://pdbe.org/7bus PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bus RCSB], [https://www.ebi.ac.uk/pdbsum/7bus PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bus ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CHS1_SOYBN CHS1_SOYBN] The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Isoflavonoid is one of the groups of flavonoids that play pivotal roles in the survival of land plants. Chalcone synthase (CHS), the first enzyme of the isoflavonoid biosynthetic pathway, catalyzes the formation of a common isoflavonoid precursor. We have previously reported that an isozyme of soybean CHS (termed GmCHS1) is a key component of the isoflavonoid metabolon, a protein complex to enhance efficiency of isoflavonoid production. Here, we determined the crystal structure of GmCHS1 as a first step of understanding the metabolon structure, as well as to better understand the catalytic mechanism of GmCHS1. This article is protected by copyright. All rights reserved. | |||
Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean.,Imaizumi R, Mameda R, Takeshita K, Kubo H, Sakai N, Nakata S, Takahashi S, Kataoka K, Yamamoto M, Nakayama T, Yamashita S, Waki T Proteins. 2020 Jul 29. doi: 10.1002/prot.25988. PMID:32725893<ref>PMID:32725893</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 7bus" style="background-color:#fffaf0;"></div> | |||
==See Also== | |||
*[[Chalcone synthase|Chalcone synthase]] | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Glycine max]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Imaizumi R]] | [[Category: Imaizumi R]] | ||
| Line 15: | Line 34: | ||
[[Category: Nakata S]] | [[Category: Nakata S]] | ||
[[Category: Nakayama T]] | [[Category: Nakayama T]] | ||
[[Category: Sakai N]] | |||
[[Category: Takahashi S]] | [[Category: Takahashi S]] | ||
[[Category: Takeshita K]] | [[Category: Takeshita K]] | ||
Latest revision as of 18:35, 29 November 2023
Chalcone synthase from Glycine max (L.) Merr (soybean)Chalcone synthase from Glycine max (L.) Merr (soybean)
Structural highlights
FunctionCHS1_SOYBN The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin. Publication Abstract from PubMedIsoflavonoid is one of the groups of flavonoids that play pivotal roles in the survival of land plants. Chalcone synthase (CHS), the first enzyme of the isoflavonoid biosynthetic pathway, catalyzes the formation of a common isoflavonoid precursor. We have previously reported that an isozyme of soybean CHS (termed GmCHS1) is a key component of the isoflavonoid metabolon, a protein complex to enhance efficiency of isoflavonoid production. Here, we determined the crystal structure of GmCHS1 as a first step of understanding the metabolon structure, as well as to better understand the catalytic mechanism of GmCHS1. This article is protected by copyright. All rights reserved. Crystal structure of chalcone synthase, a key enzyme for isoflavonoid biosynthesis in soybean.,Imaizumi R, Mameda R, Takeshita K, Kubo H, Sakai N, Nakata S, Takahashi S, Kataoka K, Yamamoto M, Nakayama T, Yamashita S, Waki T Proteins. 2020 Jul 29. doi: 10.1002/prot.25988. PMID:32725893[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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