6z2h: Difference between revisions
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<StructureSection load='6z2h' size='340' side='right'caption='[[6z2h]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='6z2h' size='340' side='right'caption='[[6z2h]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6z2h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[6z2h]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z2H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z2H FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=OAA:OXALOACETATE+ION'>OAA</scene>, <scene name='pdbligand=Q5B:(3S)-citryl-Coenzyme+A'>Q5B</scene></td></tr> | |||
<tr id=' | |||
< | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2h OCA], [https://pdbe.org/6z2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2h RCSB], [https://www.ebi.ac.uk/pdbsum/6z2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2h ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z2h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z2h OCA], [https://pdbe.org/6z2h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z2h RCSB], [https://www.ebi.ac.uk/pdbsum/6z2h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z2h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ACLY_HUMAN ACLY_HUMAN] ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.<ref>PMID:23932781</ref> | |||
==See Also== | |||
*[[ATP-citrate synthase 3D structures|ATP-citrate synthase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Verschueren | [[Category: Verschueren KHG]] | ||
[[Category: Verstraete | [[Category: Verstraete K]] | ||
Latest revision as of 18:21, 29 November 2023
Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.Citryl-CoA lyase module of human ATP citrate lyase in complex with (3S)-citryl-CoA.
Structural highlights
FunctionACLY_HUMAN ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.[1] See AlsoReferences
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